TITLE

Protective effect of green tea extract on sperm parameters and FSH and LH levels in mice treated with anti-cancer drug paclitaxel

AUTHOR(S)
Zaminpeyma, M.; Kouchesfehani, D.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p81
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The aim of this study was to investigate the protective effect of green tea extracts on the sperm parameters and FSH, LH levels in mice treated with anti-cancer drug Paclitaxel Materials and Methods: 35 male NMRI mice were divided into 7 groups: Control received Saline as Solvent. Exprimental 1 was intraperitoneally injected 0.2 mg/kg of Paclitaxel for 3 consecutive days. Exprimental 2, 3 treated with 200 mg/kg, 300 mg/kg of GTE respercively daily for 4 weeks, (i.p. injection) . Exprimental 4, 5 treated with 200 mg/kg, 300 mg/kg of GTE respercively daily for 4 weeks, (i.p. injection).starting at the second week 0.2 mg/kg of Paclitaxel for 3 consecutive days were intraperitoneally admnistered. One week after the last injection Blood samples for determination of FSH, LH levels were collected. Testicular and Body weight and sperm parameters were evaluated. Results were analysed by ANOVA test. p<0.05 was considered as significant. Results: The results showed that the green tea extract significantly elevated the parameters of sperm, count, motility and viability (p<0.05). There was a significant decrease in FSH,LH levels in Exprimental 1 (0.2 mg/kg of Paclitaxel for 3 days) as compared to Control group (p>0.05). There was a significant increase in LH, FSH levels in Experimenal 5 as compared to Experimenal 1 after treatment with green tea extract. While the increase observed in Experimental 4 was not significant (p>0.05). Conclusion: GTE has some protective effects on sperm parameters and FSH, LH levels in mice treated with anti-cancer paclitaxel that is probably associated with its anti-oxidant components such as Catechin.
ACCESSION #
96841683

 

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