TITLE

Compare methods of diagnosing genital tuberculosis in infertile women

AUTHOR(S)
Abasi, Z.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p79
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Genital tuberculosis is an important under-diagnosed factor of infertility. Iran is a developing country with 21 in 100000 incidences of pulmonary tuberculosis and 28% extra-pulmonary dieses were reported. The aim of study is compare different methods: histopathological examination (HPE), AFB smear and polymerase chain reaction deoxyribonucleic acid (PCR-DNA) and culture for diagnosing endometrial tuberculosis in infertile women. Materials and Method: We used Scopus, Embase, PubMed, World Health Organization (WHO) and scientific Iranian journals from 2000-2014. Results: Routine laboratory values are of little value in the diagnosis. An absolute diagnosis cannot be made from characteristic features in hysterosalpingogram (HSG) or laparoscopy. On evaluating against the diagnostic criteria, the sensitivity of PCR is more than HPE while HPE is further than culture. We compare results between the clinical criteria and specific diagnostic tests by Kappa measure of agreement. The culture and HPE showed mild agreement with the clinical criteria, whereas PCR showed a moderate agreement. The PCR results were negative in some cases. PCR using TRC4 primers had a higher sensitivity than IS 6110 primers in detecting clinically suspected GTB. Due to the paucibacillary nature of GTB, diagnosis by mycobacterial culture and histopathological examination (HPE) have limitations and low detection rate. Conclusion: Our results showed that conventional methods of diagnosis namely, HPE, AFB smear and culture have low sensitivity. PCR was found to be useful in diagnosing early disease as well as confirming diagnosis in clinically suspected cases. False negative PCR was an important limitation in this study.
ACCESSION #
96841677

 

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