Compare methods of diagnosing genital tuberculosis in infertile women

Abasi, Z.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p79
Academic Journal
Introduction: Genital tuberculosis is an important under-diagnosed factor of infertility. Iran is a developing country with 21 in 100000 incidences of pulmonary tuberculosis and 28% extra-pulmonary dieses were reported. The aim of study is compare different methods: histopathological examination (HPE), AFB smear and polymerase chain reaction deoxyribonucleic acid (PCR-DNA) and culture for diagnosing endometrial tuberculosis in infertile women. Materials and Method: We used Scopus, Embase, PubMed, World Health Organization (WHO) and scientific Iranian journals from 2000-2014. Results: Routine laboratory values are of little value in the diagnosis. An absolute diagnosis cannot be made from characteristic features in hysterosalpingogram (HSG) or laparoscopy. On evaluating against the diagnostic criteria, the sensitivity of PCR is more than HPE while HPE is further than culture. We compare results between the clinical criteria and specific diagnostic tests by Kappa measure of agreement. The culture and HPE showed mild agreement with the clinical criteria, whereas PCR showed a moderate agreement. The PCR results were negative in some cases. PCR using TRC4 primers had a higher sensitivity than IS 6110 primers in detecting clinically suspected GTB. Due to the paucibacillary nature of GTB, diagnosis by mycobacterial culture and histopathological examination (HPE) have limitations and low detection rate. Conclusion: Our results showed that conventional methods of diagnosis namely, HPE, AFB smear and culture have low sensitivity. PCR was found to be useful in diagnosing early disease as well as confirming diagnosis in clinically suspected cases. False negative PCR was an important limitation in this study.


Related Articles

  • Tuberculosis is still a cause of infertility in developing countries. Pant, P. R. // Journal of Institute of Medicine;Aug2010, Vol. 32 Issue 2, p33 

    Introduction: Infertility is global problem. Tuberculosis salpingitis is a very rare condition in developed countries but in developing part of the world it is still a problem. One of the commonest symptoms of pelvic tuberculosis is primary infertility. Though infrequent, pelvic tuberculosis is...

  • Endometrioid Adenocarcinoma with Endometrial Tuberculosis.  // Fertility Weekly;8/5/2002, p18 

    Primary adenocarcinoma of the endometrium associated with tuberculous endometritis should be considered in patients with postmenopausal vaginal bleeding in communities where tuberculosis is prevalent, according to researchers in Turkey. The association of endometrial cancer and genital...

  • Tuberculosis of uterine cervix: a report of two cases with variable clinical presentation. Singh, Sunita; Gupta, Veena; Modi, Shilpi; Rana, Praveen; Duhan, Amrita; Sen, Rajeev // Tropical Doctor;Apr2010, Vol. 40 Issue 2, p125 

    Tuberculosis (TB) of the cervix is a rare disease. We describe two cases of tuberculous cervicitis with variable clinical presentation. In one case, a young woman presented with primary infertility and secondary amenorrhoea. The other is a perimenopausal woman with irregular vaginal bleeding and...

  • Mycobacterium tuberculosis infection in women with unexplained infertility. Eftekhar, Maryam; Pourmasumi, Soheila; Sabeti, Parvin; Aflatoonian, Abbas; Sheikhha, Mohammad Hasan // International Journal of Reproductive Biomedicine;Dec2015, Vol. 13 Issue 12, p749 

    Background: Genital tuberculosis (GTB) is an important cause of female infertility, especially in developing countries. The positive results of polymerase chain reaction (PCR) in endometrial GTB in the absence of tubal damage raise the possibility of the detection of sub-clinical or latent...

  • Red Snappers and Red Herrings: Pelvic Tuberculosis Causing Elevated CA 125 and Mimicking Advanced Ovarian Cancer. A Case Report and Literature Review. Yates, Johnnie Alphonse; Collis, Olivia Ann; Sueblinvong, Thanasak; Collis, Tarquin Kamakana // Hawaii Journal of Medicine & Public Health;Aug2017, Vol. 76 Issue 8, p220 

    Female genital tuberculosis (FGTB) is a form of extra-pulmonary tuberculosis that has been primarily described in developing countries, where it is an important cause of infertility, ectopic pregnancy, and miscarriage. FGTB is rare in the United States and because its clinical presentation is...

  • Our own gift. Matetakufa, Sue Njanji // New Internationalist;Jul98, Issue 303, p11 

    Discusses the social stigma associated with female infertility in Zimbabwe. Comments from Professor Jonathan Kasule, head of the Department of Obstetrics and Gynaecology at the University of Zimbabwe; Type of abuse suffered by infertile women; Steps taken to conceal male infertility.

  • Trying to get pregnant. Koontz, Katy // Shape;Oct95, Vol. 15 Issue 2, p102 

    Discusses the issue of female infertility in the United States. Estimated number of couples having trouble getting pregnant; Profiles of women seeking treatment from infertility; Causes of infertility; Types of treatment. INSET: Step by step:.. (steps for infertility treatment)..

  • Margaret Nofziger on tracking fertility. Nofziger, Margaret // Nutrition Health Review: The Consumer's Medical Journal;1996, Issue 76, p6 

    Presents an advisory on women's questions on some of the finer points of tracking female fertility. Includes basal body temperature method; Cervix mucus; Diethylstilbestrol.

  • Infertility: Its Investigation and Treatment.  // Women's International Network News;Spring97, Vol. 23 Issue 2, p40 

    Presents excerpts from the article on female infertility entitled `Infertility: Its Investigation and Treatment,' from the periodical `New Generation Digest,'. Causes of female infertility; Investigation of ovulation defects.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics