Effect of progesterone supplementation on natural frozen-thawed embryo transfer cycles. A randomized controlled trial

Eftekhar, M.; Rahsepar, M.; Rahmani, E.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p71
Academic Journal
Introduction: The transfer of cryopreserved embryos can be timed with ovulation in a natural cycle or after artificially preparing the endometrium with exogenous hormones. Progesterone is essential for the secretory transformation of the endometrium that permits implantation as well as for the maintenance of early pregnancy. The purpose of this study is to assess the effect of luteal phase supplementation on pregnancy rates in natural frozen-thawed cycles. Materials and Methods: The study was designed as a prospective randomized clinical trial of 102 women undergoing an embryo transfer in a natural cycle. The women in the interventional group (n=51) received intramuscular progesterone 50 mg twice a day starting from 36 hours after the hCG administration. The control group (n=51) did not receive any progesterone support. Results: There were no significant differences of demographic characteristics between the groups and no statistically significant differences were observed between study and control groups in clinical pregnancy rate (33.3% vs. 27.5%, p=0.66). There were no differences in implantation rate or spontaneous abortion rate either. Conclusion: In conclusion, our results suggest that a luteal phase support does not affect clinical pregnancy rates in natural frozen-thawed embryo transfer cycles.


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