Evaluation effect of intrauterine human chorionic gonadotropin injection before embryo transfer in implantation and pregnancy rate in infertile patients and comparison with conventional embryo transfer in IVF/ ICSI/ ET cycles: A randomized clinical trial

Dehghani Firouzabadi, R.; Janati, S.; Mohseni, F.; Razi, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p70
Academic Journal
Introduction: Implantation is one of the key stages for the success of assisted reproductive techniques (ART). The complex process of Implantation is regulated by various factors which one the most important is human chorionic gonadotropin (HCG). This prospective, randomized clinical study aimed to investigate the effect of intrauterine human chorionic gonadotropin injection before embryo transfer (ET) on pregnancy outcome in infertile couples. Materials and Methods: Of 317 patient's candidates for IVF/ ICSI, we evaluated 159 patients undergoing Invitro Fertilization /Intracytoplasmic Sperm Injection (IVF/ICSI) with antagonist protocol. Patients divided into three groups by a computer-based program. In cases, case group I (n=53) received 500 IU of HCG and case group II, (n=53) received 1000 IU of HCG intrauterine injection before ET, and control group undergoing ET without a preceding intrauterine injection of HCG. Results: There was no significant difference between case group I, II and control group .The implantation rate was 18.86%, 13.52% and 14.37%, chemical pregnancy rate was 34%, 32.15% and 35.3%, and the clinical pregnancy rate was 32.1%, 32.1% and 31.4%, respectively in the case group I, II and control group. Conclusion: Intrauterine injection of HCG before embryo transfer (ET) does not improved the pregnancy outcomes in IVF/ICSI /ET cycles.


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