A Comparison of the effects of transdermal estradiol and estradiol valerate on endometrial receptivity in frozen-thawed embryo transfer cycles: A randomized clinical trial

Davar, R.; Janati, S.; Mohseni, F.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p70
Academic Journal
Introduction: Implantation and pregnancy are related to the interfaces between embryo maturity and endometrial receptivity. The aim of this study was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17B-estradiol transdermal patch. Materials and Methods: Of 188 women candidates for FET, 90 patients were enrolled in our study. In the study group (n=45), 17-B estradiol transdermal patches 100 fig were applied from the second day of the cycle and continued every other day. Then each patch was removed after four days .In the control group (n=45), oral estradiol valerate 6 mg started as the same time above and continued daily. Results: There was a significant difference in estradiol level on the day of progesterone administration and the day of embryo transfer between the two groups (p=0.001 in both), but no significant difference was observed between them in biochemical and clinical pregnancy rates (32.6 % vs.33.3%, p=l, 30.2%vs. 33.3%, p=0.81 respectively). The implantation rate tended to be higher in the study group, but it did not achieve a statistical significance (20.45% vs. 11.7% respectively p>0.05). Conclusion: In spite of there being no significant differences in implantation, biochemical and clinical pregnancy rates between the two groups, due to the reduced costs, drug dose, and emotional stress as well as the simplicity of the protocol for patient, we can use estradiol transdermal patches instead of oral estradiol in FET cycles.


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