Evaluation of predictive factors for clinical pregnancy rate of intrauterine insemination (IUI) cycles: the role of infertility cause

Ashrafi, M.; Rashidi, M.; Ghasemi, A.; Arabipoor, A.; Pourasghari, P.; Zolfaghari, Z.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p66
Academic Journal
Introduction: This study was conducted to identify the prognostic factors for pregnancy rates (PR) in IUI treatments within different groups according to cause of infertility. Materials and Methods: This retrospective study was performed in data of 1348 IUI cycles with ovarian stimulation by clomiphene citrate (CC) and/or gonadotropins in 632 women with five different infertility etiology subgroups at Akbarabbadi Hospital, Tehran University of Medical Science from 2008-2010. Results: The (PRs)/ cycle were highest (19.9%) among couples with unexplained infertility and lowest (10.6%) in couples with multiple factors infertility. In cases of unexplained infertility, the best PRs were seen after CC plus gonadotropins stimulation (26.3%) and with inseminated motile sperm count>30x10 (21.9%), but the tendency didn't reach statistical significant. In the ovarian factor group, the best PRs were observed in women aged between 30 and 34 years (20.8%), with 2-3 preovulatory follicles (37.8%) and infertility duration between land 3years (20.8%), while only infertility duration (p=0.03) and number of preovulatory follicles (p=0.01) were statistically significant. In male factor cases, ovulation induction with sequential CC/hMG had a significantly better result. Multiple logistic regression analysis determined that number of preovulatory follicles (p=0.02), duration of infertility (p=0.01), age (p=0.01), infertility etiology (p=0.05) and stimulation regimen (p=0.01) were significant independent factors in order to predict overall clinical PR. Conclusion: The etiology of infertility is important to achieve remarkable IUI success. It is worth mentioning that within different causes of infertility, the demographic and cycles characteristics of couples did not show the same effect.


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