Comparison of two groups with combination drug regimens in infertile women with anovulatory cycles, best pregnancy rate with least complication

Rasekh Jahromi, A.; Maalhagh, M.; Alipour, F; Hosseinpoor, M.; Alborzi, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p63
Academic Journal
Introduction: The aim of this research is comparison of two group's regimens in infertile women with anovulatory cycles, with the best pregnancy rate, least adverse effects. Materials and Methods: Randomized control trial was done on 90 infertile women referred to Dr Rasekh clinic in Jahrom city during 1 year. Patients were 2 groups randomly and each group with 45 numbers of infertile women .The majority of patients (80.7%) in both group were in the age group 20-30 years (p=0.5). Group 1 treated with Tamoxifen+ letrozole +estradiol. Group 2 treated with clomiphene+ Tamoxifen + vitamin E. some of the patient became pregnant spontaneously before finishing ovulation induction protocol. Results are reported as number and percentage and the Chi-square test. Data was analyzed by SPSS 16. Results: Group 1 were treated with Tamoxifen+letrozole+estradiol, Group 2 with clomiphene+Tamoxifen+vitamin E. pregnancy rate in group 1 was more than group 2, (17.8%:2.2%). Group 1 had better results for acceptable endometrial thickness (more than 8 mm: 91.11%) (p=0.08). OHSS in group 1 was 6.7%, which was less than group 2: (35%) (p=0.09). Patients who were treated with estradiol+Tamoxifen+letrozole had better follicular maturation (37.77% vs. 28%) (p=0.4). There are no significant statistical differences in age and size of the follicles in both groups. Conclusion: Pregnancy rate in two groups had significant difference (p=0.01) which shows the efficacy of regimen in group 1. Group 1 had better results in endometrial thickness, follicular size and also lower rate of OHSS.


Related Articles

  • Second TIME AROUND. SACKS, MEG // Jacksonville Magazine;Oct2015, p50 

    A personal narrative is presented which explores the author's experience of struggling with infertility after losing several pregnancies.

  • LETTERS. Silberstein, Elaine; Winter, Oatricia; Bermack, Nancy; Gertz, Emily; Wang, Lily; Graham, Diana; Cahalan, Lisa; Vegosen, Ariel; Rahmanan, Lisa; Donnelly, Cheryl // New York;10/11/2004, Vol. 37 Issue 35, p15 

    Presents several letters to the editor in response to the article "The Perfect Little Bump," by Laurie Abraham. Exercises needed by pregnant women; Factors contributing to women infertility; Complications involved during pregnancy.

  • Reproduction and the risk of multiple sclerosis. Magyari, Melinda; Koch-Henriksen, Nils; Pfleger, Claudia C; Sørensen, Per Soelberg // Multiple Sclerosis Journal;Oct2013, Vol. 19 Issue 12, p1604 

    The article discusses a study on the effect of childbirths and age at first birth in the development of multiple sclerosis (MS). It states that the researchers collected information on pregnancy complication, infertility, and induced abortion from the Danish National Patient Register, and...

  • Embarazo heterotópico en un ciclo de concepción natural presentado como embarazo ectópico roto. Informe de un caso. Domínguez-Meléndez, Karla Elena; Sastré-Gómez, Héctor; Higuera-Hidalgo, Francisco; Vargas-Domínguez, Armando; Zaldívar-Ramírez, Felipe Rafael // Cirugia y Cirujanos;nov/dic2008, Vol. 76 Issue 6, p519 

    Background: Heterotopic pregnancy is defined as an intrauterine pregnancy that coexists ectopically with another pregnancy. It is a rare event, in particular in patients not being treated for infertility. Our objective is to report a case of a patient without in vitro fertilization or other type...

  • POI: Premature Ovarian Insufficiency/Pregnancy or Infertility? Soave, Ilaria; Lo Monte, Giuseppe; Marci, Roberto // North American Journal of Medical Sciences;Jan2013, Vol. 5 Issue 1, p71 

    The article presents a case study a 28-year-old woman who was presented to the infertility unit with 16 months of primary infertility. She experienced menarche at age 12 along with menstrual bleeding and started to take birth-control pills at age 22. It also notes the need for considering...

  • Heterotopic Pregnancy with Spontaneous Vaginal Delivery at 36 Weeks and Laparotomy at Term -- A Case Report. Umezurike, Chisara C.; Feyi-Waboso, Paul A. // African Journal of Reproductive Health;Apr2005, Vol. 9 Issue 1, p162 

    Heterotopic pregnancy, although rare, is occurring more frequently because of an increase in genital infection and the escalating use of new reproductive technologies in infertility patients. The case of a 30-year-old para 2+1 prophetess is presented. She had a spontaneous vaginal delivery at...

  • Unembriyonic Pregnancy in a Noncommunicating Rudimentary Horn of a Unicornuate Uterus: A Case Report. Ünlü, Bekir Serdar; Aytan, Hakan; Evsen, Mehmet Sıddık; Tapısız, Ömer Lütfi; Zergeroğlu, Sema; Mollamahmutoğlu, Leyla // Journal of Turgut Ozal Medical Center;2014, Vol. 21 Issue 4, p304 

    This is a case report of an unembriyonic pregnancy in the non-communicating rudimentary horn of a unicornuate uterus with the contralateral ovary carrying a corpus luteum. A 24-year-old nullipara was admitted to our outpatient clinic with the complaint of primary infertility for 3 years. Her...

  • Expression of β3 Integrin and calcitonin in the peri-implantation period in women with unexplained infertility. Mirani, M.; Dorostghoal, M.; Ghaffari, H. A.; Sahbazian, N. // Iranian Journal of Reproductive Medicine;AprSupp, p78 

    Introduction: Embryo implantation into the uterus is a critical step in the establishment of pregnancy and failure of this process is a major cause of infertility in women. Different kinds of molecules mediate the interaction between endometrium and embryo. Expression of beta3 Integrin and...

  • Conference Abstracts.  // Fertility Weekly;1/20/2003, p21 

    Presents several abstracts of research related to fertility. "Parvovirus B-19—A Common Infectious Agent Causing Problems During Pregnancy," by S. Modrow; "The Effect of Oestrogens and Scav-oestrogens on the Generation of Reactive Oxygen Species by Sertoli Cells," by J. Berlau, U. C....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics