TITLE

Comparison of two groups with combination drug regimens in infertile women with anovulatory cycles, best pregnancy rate with least complication

AUTHOR(S)
Rasekh Jahromi, A.; Maalhagh, M.; Alipour, F; Hosseinpoor, M.; Alborzi, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p63
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The aim of this research is comparison of two group's regimens in infertile women with anovulatory cycles, with the best pregnancy rate, least adverse effects. Materials and Methods: Randomized control trial was done on 90 infertile women referred to Dr Rasekh clinic in Jahrom city during 1 year. Patients were 2 groups randomly and each group with 45 numbers of infertile women .The majority of patients (80.7%) in both group were in the age group 20-30 years (p=0.5). Group 1 treated with Tamoxifen+ letrozole +estradiol. Group 2 treated with clomiphene+ Tamoxifen + vitamin E. some of the patient became pregnant spontaneously before finishing ovulation induction protocol. Results are reported as number and percentage and the Chi-square test. Data was analyzed by SPSS 16. Results: Group 1 were treated with Tamoxifen+letrozole+estradiol, Group 2 with clomiphene+Tamoxifen+vitamin E. pregnancy rate in group 1 was more than group 2, (17.8%:2.2%). Group 1 had better results for acceptable endometrial thickness (more than 8 mm: 91.11%) (p=0.08). OHSS in group 1 was 6.7%, which was less than group 2: (35%) (p=0.09). Patients who were treated with estradiol+Tamoxifen+letrozole had better follicular maturation (37.77% vs. 28%) (p=0.4). There are no significant statistical differences in age and size of the follicles in both groups. Conclusion: Pregnancy rate in two groups had significant difference (p=0.01) which shows the efficacy of regimen in group 1. Group 1 had better results in endometrial thickness, follicular size and also lower rate of OHSS.
ACCESSION #
96841634

 

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