Sperm function tests speak louder than conventional semen analysis toward the dark edges of unexplained infertility

Aliyari, M.; Mohammadzadeh, J.; Nemati, N.; Shahsavan, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p62
Academic Journal
Introduction: Reactive Oxygen Species (ROS) and DNA fragmentation have a great role in unexplained infertility. Materials and Methods: We examined a great number of articles based on keywords such as DNA-Damage, Oxidative Stress, ROS, Acrosome Reaction ,Apoptosis, Varicocele and etc. Results: The oxidative stress, varicocele and DNA fragmentation have important impacts on the male fertility potential. Conclusion: Our observations indicate that with an exact and proper approach toward the monster of unexplained infertility with techniques such as Sperm Deformity Index (SDI), DNA Fragmentation Index (DFI), Acrosome Index (AI) and Magnetic Activated Cell Sorting (MACS), we will be able to overcome to some great problems about this important matter, especially in the era of assisted reproduction and its outcomes.


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