Application of anti-mullerian hormone (AMH) in female reproduction

Mohammadzadeh, J.; Aliyari, M.; Nemati, N.; Shahsavan, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p62
Academic Journal
Introduction: Anti-Milllerian hormone (AMH) is a dimeric glycoprotein, a member of the transforming growth factor (TGF) superfamily. In the ovary AMH is produced by the granulosa cells of early developing follicles and seems to be able to inhibit the initiation of primordial follicle growth and FSH induced follicle growth. Materials and Methods: This research designed based on evaluation of 35 articles for about AMH in variety of clinical situations. Results: levels of AMH may represent both the quantity and quality of the ovarian follicle pool. Compared to other ovarian tests, AMH seems to be the best marker reflecting the decline of reproductive age. AMH values have greater sensitivity than Inhibin B, FSH and Estradiol values in predicting ovarian follicular reserve, but combining AMH, Inhibin B and FSH modestly improves the predictive statistics. This predictive value could be improved in poor responders by combining the measure of AFC with these biochemical markers. AMH measurement could be useful in the prediction of the menopausal transition, ovarian reserve; polycystic ovary syndrome (PCOS) and ovarian cancer .Furthermore predicted early menopause with AMH measuring could emphasize the need for timely prevention of bone demineralization and cardiovascular diseases. It could also be used to predict poor ovarian response and prognosis of in vitro fertilization (IVF) cycles. Conclusion: In this article we have shown that AMH can be a novel marker to prediction or diagnosis a spectrum of clinical situations from ovarian reserve to ovarian cancer.


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