The relationship between serum anti-Mullerian hormone level and endometriosis to ovarian response during Assisted Reproductive Technology cycles

Hosseini, E.; Nikmard, F.; Alenabi, T.; Aflatoonian, A.; Aflatoonian, B.; Aflatoonian, R
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p60
Academic Journal
Introduction: AMH is not only associated with the oocyte yield after IVF but also is associated with oocyte quality and embryo number, making it a prognostic factor for the chance of a pregnancy and live birth. Several investigators demonstrated lower basal AMH levels among women with endometriosis. However, there are few studies for correlation between serum AMH and ovarian response to COH in women with endometriosis. Materials and Methods: Retrospective data were collected from 126 infertile women undergoing ICSI treatment with the long stimulation protocol. Patients divided into two groups: 66 women with endometriosis diagnosed by laparoscopy and 60 women with tubal factor (study and control groups). AMH level, oocyte and early cleavage embryo number and pregnancy rate were measured. Results: Serum AMH levels were significantly lower in endometriosis compared to the control group (1.99±0.16 vs. 2.65±0.23 ng/mL). In endometriosis patients the mean of retrieved oocytes (7.47±0.61) and embryo number (4.58±0.45) were significantly lower compared with control group (10.12±0.85, 6.78±0.62). The chemical pregnancy rate in women with and without endometriosis was 15 and 37%, respectively. Conclusion: Although ART procedures have been successful in infertile women with endometriosis, poorer results are still expected for these patients. Our data shows that endometriosis patients have a reduced reproductive potential because of decreased AMH levels and consequently, lower retrieved oocytes, embryo number and pregnancy rate. This finding suggests that endometriosis is associated with the reduction of ovarian reserve and poorer results in terms of Control Ovarian Hyperstimulation.


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