TITLE

Comparison of GnRH antagonist versus GnRH agonist on ART outcomes in patients with poor ovarian response

AUTHOR(S)
Zeinalzadeh, M.; Yousefniapasha, Y.; Jorsaray, G.; Firoozpour, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p58
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Studies revealed that 9-24% of women who underwent ovarian stimulation induced by gonadotropins for infertility treatment represented weak ovulatory responses. The aim of the study was to compare IVF outcomes in poor-responder patients undergoing GnRH agonist protocol versus administration of GnRH antagonist protocol. Materials and Methods: One hundred poor responded s women were randomly assigned into two groups of GnRH agonist recipient and GnRH antagonist. Trans-vaginal ultrasound and measurement of serum estradiol E? were utilized in order to assess the maturity of the follicles. Ultimately, cancellation rate, number of oocytes retrieved, and clinical pregnancy rates and features of cycle between two groups. Results: Comparing duration of gonadotropin-induced stimulation, number of retrieved acolytes, total rate of cycle abolition, and incidence rate of clinical pregnancy were not significantly different between two groups. Conclusion: According to our findings, GnRH agonist appears to be as efficacious as GnRH antagonist protocol in poor responder women undergoing ovarian stimulation in IVF process.
ACCESSION #
96841621

 

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