Routine use of EmbryoGlue® as embryo transfer medium does not improve the ART outcomes

Razi, M. H.; Safari, S.; Razi, Y.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p58
Academic Journal
Introduction: The aim was to investigate the assisted reproductive technology (ART) outcomes in unselected patients after the routine use of EmbryoGlue® as a human embryo transfer (ET) medium with high concentration of hyaluronan (HA, hyaluronic acid). Materials and Methods: A total of 229 unselected patients were retrospectively enrolled in the present study. They were divided into two groups: study group (n=117) that day 2 embryos were transferred in EmbryoGlue® and control group (n=112) that day 2 embryos were transferred in a conventional ET medium (with low concentration of HA). Results: Patients in both groups, in regards to the mean of day 3 FSH levels, etiology of infertility, and history of previous implantation failure, and high rate of good quality embryos were similar. There were no significant differences between two groups in regards to clinical and ongoing pregnancies, implantation, and delivery and live birth rates. In spite of decreased abortion rate and increased multiple pregnancy rates in study group, the differences were insignificant. Conclusion: Routine use of EmbryoGlue® as a HA enriched transfer medium for cleaving stage embryos may not be a beneficial option for all patients undergoing ART.


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