Association of obesity with polycystic ovary morphology

Esmaeilzadeh, S.; Ghanbari Andarieh, M.; Agajani Delavar, M.; Ghadimi, R.; Golsorkhtabaramiri, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p57
Academic Journal
Introduction: To evaluate the relevance of body mass index (BMI), with Polycystic ovary morphology in polycystic ovary syndrome (PCOS) women. Materials and Methods: We reviewed the medical records of all women visited in the PCOS Clinic of Babol, Iran, from 2008-2012. A retrospective cross-sectional study was conducted on 175 PCOS women: 18-38 years diagnosed based on the Rotterdam criteria. Results: Positive finding of polycystic ovaries was observed in 89.1% of PCOS women with by using sonography. A total of 69.2% overweight/obesity patients had polycystic ovary morphology on ultrasound image. Compared with non- overweight/obesity, the adjusted OR of PCOS women for sonographic view of polycystic ovaries was 4.33 (95% CI, 1.42-13.15, p=0.010), Nevertheless, the adjusted odds ratio (OR) showed no significant associations between LH, FSH, and LH/FSH ratio with clinical symptoms in these women. Conclusion: The findings of the present study indicated that the overweight/obese women with PCOS are at an increased risk for sonographic view of polycystic ovaries. Therefore, it is suggested that successful weight loss is the most effective method of restoring ovulation, menstruation that should be used as major advice in obese PCOS patients.


Related Articles

  • A STUDY OF PATHOGENESIS OF ACANTHOSIS NIGRICANS AND ITS CLINICAL IMPLICATIONS. Puri, Neerja // Indian Journal of Dermatology;Nov/Dec2011, Vol. 56 Issue 6, p678 

    Background: Acanthosis nigricans (AN) is a dermatosis characterized by thickened, hyperpigmented plaques, typically on the intertriginous surfaces and neck. Common in some populations, its prevalence depends on race. Clinicians should recognize AN; it heralds disorders ranging from...

  • A Study on Fat Mass and Obesity Associated (FTO) Gene rs9939609 Variant in Egyptian Women with Polycystic Ovarian Syndrome. Osman, Hussein G.; El-Refaeey, Abdel Aziz A.; El-Sokkary, Ahmed M. A.; El-Sokkary, Mohamed M. A.; El-Saeed, Rasha A. // Australian Journal of Basic & Applied Sciences;Aug2014, Vol. 8 Issue 13, p98 

    Variations in the fat mass and obesity associated (FTO) gene have recently been associated with obesity among different ethnic populations. Given that the phenotype of polycystic ovary syndrome (PCOS) overlaps with obesity, it has been hypothesized that the common rs9939609 variant of FTO gene...

  • Effect on BMI Improves Metabolic Disturbance and can Improve Chance of Conception.  // Fertility Weekly;2/21/2011, p3 

    The article discusses a study on the effect of weight on pregnancy and its influence on fertility and metabolism. According to state researchers, women with normal body mass index (BMI) have higher chances of fertility rates in natural or assisted insemination. It notes the influences of obesity...

  • Metformin 2,500 mg/day in the treatment of obese women with polycystic ovary syndrome and its effect on weight, hormones, and lipid profile. Aghahosseini, Marzieh; Aleyaseen, Ashraf; Safdarian, Leli; Moddaress-Hashemi, Shahab; Mofid, Behshad; Kashani, Ladan // Archives of Gynecology & Obstetrics;Dec2010, Vol. 282 Issue 6, p691 

    Purpose: The objective of this study was to assess the efficacy and safety of metformin at the dosage of 2,500 mg/day in the treatment of obese women with PCOS and also to evaluate its effect on weight, hormones, and lipid profile. Method: This study was a 4-month open-label clinical trial....

  • Metformin Aids Weight Loss and Metabolic Parameters Following Rimonabant Therapy.  // Fertility Weekly;3/2/2009, p3 

    The article reports on the study in Great Britain regarding how metformin helps obese polycystic ovary syndrome (PCOS) patients achieve weight loss and metabolic parameters following rimonabant therapy. It states that rimonabant and metformin are used to improve insulin resistance and...

  • Association between circulating adiponectin levels and polycystic ovarian syndrome. Mirza, Saira Saeed; Shafique, Kashif; Shaikh, Abdul Rauf; Ali Khan, Naveed; Qureshi, Masood Anwar // Journal of Ovarian Research;2014, Vol. 7 Issue 1, p2 

    Background Low adiponectin levels in polycystic ovarian syndrome (PCOS) have been largely attributed to obesity which is common among these patients. In addition, evidence also suggests that low adiponectin in PCOS may be related to insulin resistance (IR) in these women. However, studies on the...

  • LH Dynamics in Overweight Girls with Premature Adrenarche and Slowly Progressive Sexual Precocity. Bordini, Brian; Littlejohn, Elizabeth; Rosenfield, Robert L. // International Journal of Pediatric Endocrinology;2010, p1 

    Background. Excess adiposity and premature adrenarche (PA) are risk factors for the development of polycystic ovary syndrome (PCOS). Methods. Girls with slowly progressive precocious breast development, who were overweight and had PA (SPPOPA, 6.2- 8.2 years, n = 5), overweight PA (6.6-10.8...

  • Genome-wide association study identifies GYS2 as a novel genetic factor for polycystic ovary syndrome through obesity-related condition. Hwang, Joo-Yeon; Lee, Eun-Ju; Jin Go, Min; Sung, Yeon-Ah; Lee, Hye Jin; Heon Kwak, Soo; Jang, Hak C; Soo Park, Kyung; Lee, Hye-Ja; Byul Jang, Han; Song, Jihyun; Park, Kyung-Hee; Kim, Hyung-Lae; Cho, Myeong-Chan; Lee, Jong-Young // Journal of Human Genetics;Oct2012, Vol. 57 Issue 10, p660 

    To investigate the role of genetic predisposition in the pathogenesis of polycystic ovary syndrome (PCOS) in relation to obesity, we performed a genome-wide association study of PCOS in Koreans (n=1741). PCOS is a heterogeneous endocrinal disorder of uncertain etiology. Obesity is one of the...

  • Insulin Resistance and Lipid Accumulation Product in Correlation to Body Mass Index in Women with Polycystic Ovary Syndrome. Godinjak, Amina; Godinjak, Zulfo; Burekovic, Azra; Surkovic, Ismana; Dizdarevic-Bostandzic, Amela; Velija-Asimi, Zelija // Medical Archives / Medicinski Arhiv;2012, Vol. 66 Issue 6, p409 

    Introduction: Women with Polycystic Ovary Syndrome (PCOS) are at increased risk for cardiovascular morbidity and metabolic disorders including: dyslipidaemia, hypertension, insulin resistance, gestational diabetes, type 2 diabetes, systemic inflammation and endothelial dysfunction. The...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics