TITLE

The predictors of single-dose methotrexate treatment failure in women with ectopic pregnancies

AUTHOR(S)
Azargoon, A.; Ghorbani, R.; Mosavi, S.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p56
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The aim of this study is to determine the predictors of treatment failure in single dose of MTX injection. Materials and Methods: In this quasi-experimental trial, we studied 70 women with ectopic pregnancies who were treated with MTX, according to a single dose protocol. Patients were considered a treatment success if BHCG levels decreased ⩽10 m IU/ml after first dose of MTX. Treatment failure was defined as the need for a second or third dose of MTX and or surgery. The following risk factors were compared between the two groups: serum BHCG on days 1 and 4, ⩾15%falls in serum BHCG between days 1-4 treatment, age, parity, gravidity, and size of ectopic mass and endometrial thickness. Results: The success rate of MTX treatment was 77.1%). There were no significant differences between two groups in regards with the age, parity, gravidity, size of ectopic mass and endometrial thickness, but the mean serum BHCG concentration on days 1 and 4 were lower in the success group rather than failure group. We also observed ⩾15% fall in serum BHCG in 80.9% of the women with success and 38.5% of the cases in which treatment had failure. Conclusion: Among women with ectopic pregnancies, a high serum BHCG concentration on days 1-4 and ⩽15% fall in serum BHCG between days 1-4 treatment are the most important factor associated with failure of treatment with a single dose MTX protocol.
ACCESSION #
96841615

 

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