The relation between anti-Mullerian hormone and antagonist protocol in women undergoing intracytoplasmic sperm injection

Nikmard, F.; Hosseini, E.; Alenabi, T.; Aflatoonian, A.; Aflatoonian, B.; Aflatoonian, R.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p56
Academic Journal
Introduction: AMH levels correlated significantly with the number of antral follicles, so in high, normal and poor responders is decreased, respectively. AMH-tailored stimulation improved positive clinical outcomes, reduced the incidence of complications and financial burden in ART. Agonist and antagonist protocols administration in women with various range of AMH showed different outcomes therefore we intend to study of antagonist protocols' results. In This retrospective study we assessed 94 women with tubal factor infertility undergoing antagonist protocol. Materials and Methods: In our study, patients divided into group 1 (AMH<1.1 ng/ml), group 2 (1.1⩽AMH <2.8 ng/ml) and group 3 (AMH ⩾2.8 ng/ml). Results: The oocyte number in group 3 (15.6±0.68), group 2 (9.17±0.46) and group 1 (3±0.13) is significantly decreased. Embryos number in group 1 (2±0.19) is significantly lower than group 2 and 3(7±0.47 and 7.4±0.55, respectively). Pregnancy rate in group 2 is significantly higher than group 3 and 1(72%, 20% and 0%, respectively). Good quality oocytes average in group 3 is significantly higher than other groups (5.8±0.62) and in group 1 is lower than group 2 (2±0.13 and 3.53±0.29, respectively). Good quality embryos average in group2 and 3 (2.35±0.13 and 2.5±0.23, respectively) is significantly higher than group 1 (1±0). Conclusion: Results determined increasing AMH levels associated with good quality oocytes and embryos. We observed the highest pregnancy rate in normal range of AMH, thus perhaps antagonist protocol in certain range of AMH levels can lead to optimal results. In AMH <1.1 ng/ml, antagonist protocol lead to suboptimal results, it can be concluded that it isn't proper for them. Therefore, AMH levels may be used for selection of optimal protocol.


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