TITLE

Evaluation of vaginal misoprostol effect on pregnancy rate after IUI

AUTHOR(S)
Zahiri Soruri, Z.; Asgharnia, M.; Gholampoor, A.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p55
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Intrauterine inseminator (IUI) is one of the most appropriate and cost-effective methods of assisted reproductive technologies (ART). As, distinguishing factors which could elevate its efficacy is helpful, we aimed to investigate effect of vaginal misoprosul on pregnancy rate after IUI. Materials and Methods: This is a double blind, placebo controlled trial which was conducted on 210 infertile women referred to infertility clinic of Alzahra Hospital by an indication for IUI during 2012-2013. Women were divided in 2 groups. 200 mg vaginal misoprostol and 200 mg vaginal placebo had been administered for first and second group after IUI, respectively. Patients were followed for 2 weeks and lack of menstrual period indicated performing (3-HCG test. Results: Pregnancy had been noted in 24 misoprostol (22.9%) and 27 placebo (25.7%) groups which showed no significant difference. Also, there were no significant difference between age groups regarding BMI, causes, types and duration of infertility, sperm motility, sperm count and number of follicoles (p>0.05). In misoprostol group, 3 nausea and vomiting (2.9%) had been observed. Conclusion: According to the results, administering 200 mg vaginal misoprostol didn't have any effect on pregnancy rate. Also, there was no significant difference between groups in terms of other variables.
ACCESSION #
96841613

 

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