Effects of metformin treatment on serum, follicular fluid parameters and oocyte quality in PCOS patients undergoing ICSI

Cheraghi, I.; Soleimani Mehranjani, M. A.; Shariatzadeh, M.; Nasr Esfahani, M. H.; Ebrahimi, Z.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p55
Academic Journal
Introduction: Polycystic ovarian syndrome (PCOS) is usually distinguished by an increasing number of oocytes; however, these are often of low quality leading to lower fertilization, cleavage and implantation rates. The purpose of the present study was to investigate the effects of metformin on follicular fluid parameters, oocyte and embryo quality in PCOS women undergoing ovulation induction for ICSI. Materials and Methods: A prospective randomized, placebo controlled trial study was conducted in the IVF Unit of Infertility Research Center of the ACECR Qom. 40 cases of PCOS in the age of 25-35, all patients with PCOS undergoing ICSI treatment using a long GnRH agonist protocol and were treated for six weeks with Metformin (MET Group; 500 mg three times daily, n=20) and Placebo (Control Group, n=20). In each cases, clinical and biochemical evaluations in serum and follicular fluid were performed. Data were analyzed with t-test and Mann-whitney tests. Results: After treatment, levels of serum insulin, leptin, LH, TT, Cholesterol and Triglyceride were significantly differences in the MET group compared with the placebo. The levels of follicular fluid leptin, insulin and LH were significantly different in the MET group compared with placebo. Mature and normal oocytes significantly increased in the MET group compared to placebo. Conclusion: It can be concluded that metformin promotes lipid profile, endocrine and hormonal levels, improvement of oocyte maturation and quality, ovulation, and consequently the long-term health status of women with PCOS.


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