Assessment of some endometrial cytokines association with In Vitro fertilization (IVF) outcome

Rabiee, S.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p53
Academic Journal
Introduction: Cytokines which produce by fetal and uterine mucus are responsible for regulation interactions between mother and fetus that improve uterus receptivity and leads to higher success rate of in vitro fertilization (IVF). The aim of the present study was to evaluate the relationship between levels of some cytokines (IL-1β, TNF-α, IP-10, and MCP) in endometrial secretion with success rate of IVF procedures. Materials and Methods: In a nested case-control study, 50 consecutive women who were candidate for IVF due to infertility and referred to the clinics of Fatemieh Teaching Hospital in Hamadan were enrolled. Aspiration of endometrial secretion was performed in all women prior to embryo transfer using trans-cervical catheter insertion. The level of cytokines in aspirated fluid was determined by ELISA assay and using especial standard kits. Results: Among 50 enrolled women, 5 samples initially excluded because of contact bleeding within sampling and thus aspirated endometrial secretions of 45 women were analyzed to assess level of the cytokines. Comparing levels of cytokines in aspirated endometrial secretions showed lower concentrations of TNF-a, IP-10, and MCP in the group who experienced successful clinical pregnancy (n=9) than the group with failed pregnancy (n=36), however no significant difference was revealed in level of IL-If3 between the two groups. Conclusion: In IVF patients with implantation failure, an elevated level of TNF-a, IP-10, and MCP cytokines are observable. Low levels of these cytokines can be valuable predicting markers for successful IVP pregnancy.


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