TITLE

The role aspirin on the spermatogenesis and blood level of Testosterone and ICSH, FSH in mouse

AUTHOR(S)
Verdi, A.; Parivar, K.; Sadoghi, M.; Kaka, Gh. R.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p41
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Aspirin is a drug which is commonly used in relief of pains from slight to moderate status. The present research investigated the role of Aspirin on number and motility of sperm, spermatogenesis, and ICSH, FSH, testosterone hormones in mature male NMRI mouse. Materials and Methods: In this research, the number 24 mature male NMRI mouse were divided in to 4 groups (n=6) including control group, sham group, experimental group 1 (received 300 mg/kg in human) and experimental group 2 (received 450 mg/kg in human). The treatments were injected intraperitoneally for 6 days. Data were compared analyzed with Spss software tukey test. Results: No morphological change in results between control group and treated with aspirin showed testicular. Also in number and motility of sperm count between these groups no significant changes were observed. But the number of spermatogonia A, B, primary spermatocyt, spermatids and permatozoa cells in the testes tissue and spermatozoa in the epididymis experimental group was significant decrease than the control group. Result Significant increase in both the experimental group than control group in the thickness of tunica albuginea showed. But no significant change in ICSH, FSH and Testosterone hormones level. Conclusion: In a general conclusion that aspirin could reduce spermatogenesis decrease and thickness of tunica albuginea increase.
ACCESSION #
96841578

 

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