TITLE

The effect of curcumin on lipid peroxidation and antioxidant capacity in serum and testes in cadmium chloride- treated mice

AUTHOR(S)
Atabaki, Z.; Momeni, H.; Chehreii, Sh.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p41
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Cadmium is an environmental pollutant and heavy metal that exerts their destructive effects through the induction of oxidative stress. Curcumin is known as a strong antioxidant inhibits that is able to oxidative stress. The aim of present study was to investigate the effect of curcumin on the adverse effect of cadmium on lipid peroxidation and antioxidant capacity in serum and testes in mouse. Materials and Methods: Adult mice were divided into 4groups: 1.Control 2. Cadmium (5 mg/kg) 3. Curcumin (100 mg/kg) 4. Curcumin+ Cadmium. At the end of treatment (24 hours), blood serum was prepared from animals and their testes were dissected. To study lipid peroxidation of serum and testis, the amount of malonyldialdehyde (MDA) was measured by thiobarbituric acid while antioxidant capacity of serum and testis were measured using Ferric Reducing/Antioxidant Power (FRAP). Results: Cadmium significantly increased the level of MDA in serum and testis compared to control group. In curcumin + cadmium group, curcumin was able compensate the level of serum and testis MDA to cadmium compensate significantly the control. In addition, cadmium caused a significant reduction in serum and testis antioxidant capacity compared to the control. In curcumin + cadmium group, curcumin could significantly compensate reduced antioxidant capacity in serum and testis compared to cadmium. Conclusion: Curcumin as a potent antioxidant can reverse the adverse effect of cadmium on lipid peroxidation and antioxidant capacity.
ACCESSION #
96841577

 

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