Comparison of Zaditen and NAC on semen parameters of individuals with varicocele after varicocelectomy

Deemeh, M.; Arbabian, M.; Tavalaee, M.; Abbasi, H.; Nasr-Esfahani, M. H.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p39
Academic Journal
Introduction: Varicocele is considered as defect in pampiniform vein and correlate with poor semen quality, increase of mast cells as corporate cells in inflammatory and ROS levels. Varicocelectomy, the surgical correction of varicocele, and can be along with/without drug treatment. Some studies suggested that drug application after surgery may be useful for improvement of semen quality. Therefore we aimed to compare NAC (N-Acetyl cysteine) as an anti-oxidant and Zaditen drug as mast cell blocker after varicocelectomy in individuals with varicocele. Materials and Methods: Individuals with varicocele (N=67) in the day of varicocelectomy randomly were divided in two groups: Zaditen and NAC. These drugs were used 3 month after varicocelectomy and semen sample were collected. Improvement rate of semen volume, concentration, total and progressive motility, and sperm morphology were assessed according world health organization (WHO 2010) guidelines and data was analyzed with SPSS 18.5 Software. Results: Semen parameters were improved significantly after surgery compared to before surgery in both groups (p<0.05). But rate of improvement in Zaditen group was significantly (p<0.05) higher than NAC group in sperm concentration, total and progressive motility and total sperm count, after surgery. Conclusion: Zaditen as mast cells blocker improved semen quality rather than NAC as anti-oxidant via reducing inflammatory in testis and seminiferous tubule. We proposed application of Zaditen after varicocelectomy. For more reliable recommendation, studies on large population of individuals with varicocele were suggested.


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