TITLE

Relationship between oocyte perivitelline severe debris abnormality and intracytoplasmic sperm injection outcomes

AUTHOR(S)
Fadavi Islam, M.; Roustaei, H.; Mansouri Torshizi, M.; Sabouri, E.; Naghavizadeh, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p37
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: One of the extracytoplasmic oocyte dysmorphisms is presence of debris in perivitelline space. Reason for this phenomenon is still not exactly clear. Only one article had been published that showed the relation between perivitelline space debris and high doses of gonadotropins in ICSI cycles. Our study had focused on the effects of sever perivitelline debris on the ICSI outcome. Materials and Methods: In this retrospective study 1164 metaphase II oocytes were assessed in 100 ICSI cycles from April 2012 to December 2013 in Novin Infertility Treatment Center (Mashhad, Iran). Patients were grouped as follow: A: whom does not have any clear dysmorphisms in their all oocytes (As control group), and B: whom have sever granularity in the perivitelline space of all oocytes (as polar body could not be diagnosed clearly). Both groups received similar stimulation protocols. Oocyte morphology was assessed just before sperm injection (3-4 hours after retrieval) using inverted microscope under 400 magnification. SPSS 19 was used to data analysis. Results: There were no statistical significant differences between two groups in embryo quality, Mil oocyte and pregnancy rate. But Normal fertilization rate was significantly lower in experimental group and was affected by this abnormality. Conclusion: Our result demonstrated that sever perivitelline debris, in spit of reducing fertilization rate, doesn't have any effect on embryo quality and pregnancy rate. The mechanism to explain this result is not clear.
ACCESSION #
96841567

 

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