TITLE

Pinopode formation upon progesterone and hCG treatments as luteal phase support

AUTHOR(S)
Kabir-salmani, M.; Favaedi, M.; Taheripanah, R.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p36
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Induction of ovulation is one of the primary steps in assisted reproduction while considered as one of the main reasons for endometrial inadequacy. Hormonal treatment as a luteal phase support appeared to improve pregnancy rates, however, little is known about endometrium status following hormone therapies. Materials and Methods: Study participants were randomized into designed experimental groups receiving progesterone or hCG following ovarian hyperstimulation with a long protocol method of a GnRH agonist. One piece of endometrial biopsies was used for dating and other biopsy samples were processed for scanning electron microscopy and were examined for the area-related numerical densities of pinopodes and were statistically evaluated. Results: Statistical analysis indicated that density of pinopodes in biopsies taken from patients who received progesterone treatment as a luteal phase support were significantly (p<0.05) higher than those who received hCG treatment and those who received no treatment as well as those in natural control group. There was no significant difference between pinopode density of patients who received hCG or no treatment following GnRH agonist-stimulated cycles with those of the natural control group. Conclusion: To the best of our knowledge, this is the first prospective randomized study to provide morphological information regarding the area-related numerical density of pinopodes as one of the histological criteria of endometrium following hormone therapy in ART cycles. These data demonstrated that progesterone following GnRH agonist-stimulated cycles increased density of pinopodes which are the first embryo-fetal contact sites and considered as potential biomarker of endometrial receptivity.
ACCESSION #
96841566

 

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