Laser assisted zona hatching does not improve live birth rate in patients undergoing their first ICSI cycles

Halvaei, I.; Razi, M. H.; Razi, Y.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p34
Academic Journal
Introduction: Routine use of assisted hatching (AH) following ICSI is a controversial issue in the literature. There are rare studies regarding the effect of laser assisted hatching (LAH) on live birth rate. Our main goal was to evaluate the effect of LAH on delivery rate as well as congenital anomaly in patients undergoing their first 1CSI cycle. Materials and Methods: A total of 182 patients subjected to ICSI were randomly aliquot into two groups of experiment and control. In experiment group, the embryos were subjected to LAH to open a hole in ZP (about 10-12 μm) while in control group, the transferred embryos were intact with no AH. The patients were followed for clinical pregnancy and delivery rate as well as congenital anomaly. All the patients were infertile due to male factor infertility and LAH and embryo transfer were done on day 2. Results: Laboratory and clinical characteristics of two groups of experiment and control were the same. There were insignificant differences between two groups of experiment and control for clinical pregnancy rate (20% vs. 23.9%, respectively, p=0.3) and live birth rate (11.11% vs. 8.6%, respectively, p=0.6). Also no significant differences were observed between two groups of experiment and control for multiple pregnancy as well as congenital anomaly. Conclusion: Routine use of LAH in first ICSI cycle for male factor patients may have no beneficial effects on clinical pregnancy and live birth rate.


Related Articles

  • Registro chileno de técnicas de reproducción asistida, 2010. Schwarze Juan Enrique, M. // Revista Chilena de Obstetricia y Ginecología;Mar2013, Vol. 78 Issue 2, p82 

    Aims: To present the Chilean Registry of Assisted Reproductive Technologies performed in 2010. For the first time this registry is performed on a case-by-case basis. Results: Seven centres reported 1,238 cycles: 143 in vitro fertilization cases (IVF); 1,087 intracytoplasmatic sperm injection...

  • No Negative Influence on Outcomes of IVF or ICSI. Homer, L. // Fertility Weekly;1/14/2013, p2 

    The article reports on the results of a study led by L. Homer which revealed that the 45,X/46,XX mosaicism with 6-28 percent aneuploidy has no negative influence on the outcomes of in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). It discusses how the study was conducted...

  • Effect on Reproductive Outcome.  // Fertility Weekly;8/20/2012, p4 

    The article focuses on a report from Belgium and the Netherlands which explores the effect of chronic endometritis on reproductive outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) for asymptomatic infertile patients. The report suggests that the reproductive outcome...

  • Ovarian reserve markers and assisted reproductive technique (ART) outcomes in women with advanced endometriosis. Wahd1, Safiya A.; Al Alaf, Shahla K.; Al-Shawaf, Talha; Al-Tawil, Namir G. // Reproductive Biology & Endocrinology;2014, Vol. 12 Issue 1, p1 

    Background The role of ovarian reserve markers as predictors of the controlled ovarian stimulation (COS) response in intracytoplasmic sperm injection (ICSI) cycles in women with endometriosis has been much debated. The aim of the present study is to assess the predictability of ovarian reserve...

  • A moratorium on breeding better babies. Mertes, Heidi // Journal of Medical Ethics;Nov2014, Vol. 40 Issue 11, p734 

    The article presents brief information on the artificial reproduction technologies (ARTs). It argues the importance of genetic parenthood and asks whether these are essential philosophical questions that are not raised very frequently. It also mentions that desire for genetic parenthood is...

  • Impact of oxygen concentrations on fertilization, cleavage, implantation, and pregnancy rates of in vitro generated human embryos. Zhao-Feng Peng; Sen-Lin Shi; Hai-Xia Jin; Gui-Dong Yao; En-Yin Wang; Hong-Yi Yang; Wen-Yan Song; Ying-Pu Sun // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 4, p6179 

    The aim of the present study was to determine the impact of oxygen concentration during in vitro culture of human oocytes and embryos on fertilization, cleavage, implantation, pregnancy, multiple gestation and abortion rates. Women 20-48 years old presenting for infertility treatment and...

  • The Use of In Vitro Fertilization in the Management of Male Infertility: What the Urologist Needs to Know. Stephens, Sahar M.; Arnett, Daniel M.; Meacham, Randall B. // Reviews in Urology;2013, Vol. 15 Issue 4, p154 

    Infertility affects approximately 10% to 20% of reproductive-age couples, many of whom may present initially to a urologist. Some couples may be treated medically to increase spontaneous conception rates; however, many will require more aggressive management with in vitro fertilization (IVF)...

  • Effect of Ethnicity on Live Birth Rates.  // Fertility Weekly;6/9/2014, p1 

    The article discusses the study conducted in Great Britain suggesting that White European women have higher live birth rates following in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) than those achieved by ethnic groups. It notes that the study's objective was to evaluate...

  • The Benefits of Adding GnRH Agonist for Luteal Support.  // Fertility Weekly;5/21/2012, p5 

    The article presents a study conducted by researchers D. Kyroue and colleagues which focuses on the benefits of adding luteinizing hormone releasing hormone (GnRH) agonist for luteal support. The study shows that adding GnRH agonist during the luteal phase as part of intracytoplasmic sperm...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics