TITLE

Deltamethrin-induced RNA damage resulted in follicular cells apoptosis in rats ovary

AUTHOR(S)
Mirzakhani, N.; Tehrani, A.; Amani, S.; Baghban-Jaldian, A.; Razi, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p33
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Deltamethrin (DMT) is a broad-spectrum pyrethroid insecticide that acts by interfering with nervous system of insects and pests. Several reports indicated that insecticides are able to impact reproductive system and exert adverse effects on spermatogenesis and follicular growth processes, both in male and female genders. Present study was carried out in order to evaluate the effect of AMT on follicular growth, RNA content of follicular cells as well as serum levels of estrogen and progesterone. Materials and Methods: Twenty four mature female rats were randomly divided into 4 groups as; control-sham (received 0.5 mL corn oil, orally), low dose (1 mg/kg, orally), medium dose (3 mg/kg, orally) and high dose (7 mg/kg, orally) DMT-received groups. After 14 days, the ovarian tissue dissected out and total follicles and total normal follicles were counted per ovary. The follicular cells RNA damage was assessed by using epi-fluorescent analyses. Results: DMT resulted in significant (p<0.05) decrease total follicle contents of the ovaries as well as total normal follicle distribution in a dose dependent manner. Animals in DMT-treated groups showed intensive RNA damage in granulosa and theca cells. No histological changes were manifested in control-sham animals. Conclusion: Our data suggest that, DMT reduces follicular growth as well as total normal follicles on the ovary. Moreover, DMT exerts its impact partly via enhancing RNA damage especially in granulosa and theca cells.
ACCESSION #
96841557

 

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