TITLE

Effect of sildenafil citrate on endometrial preparation and outcome of frozen-thawed embryo transfer cycles: a randomized clinical trial

AUTHOR(S)
Dehghani Firouzabadi, R.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p31
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Sildenafil citrate may increase endometrial thickness and affect the outcome of frozen-thawed embryo transfer cycles. Objective: The aim of this study was to estimate the effect of sildenafil citrate on ultrasonographic endometrial thickness and pattern and to investigate the estrogen level on the day of progesterone administration, the implantation rate and chemical pregnancy rate in frozen embryo transfer cycles. Materials and Methods: This randomized controlled trial was conducted on 80 patients who had an antecedent of poor endometrial response and frozen embryos. 40 patients were given estradiol by a step up method with menstruation to prepare the endometrium, and the other 40 were given sildenafil citrate tablets (50mg) daily in addition to the above treatment protocol from the first day of the cycle until the day progesterone was started. This was discontinued 48-72 hours prior to the embryo transfer. Results: The endometrial thickness was significantly higher in the sildenafil citrate group (p<0.0001), the triple line patterns of the endometrium were significantly higher in the sildenafil citrate group (p<0.0001), while the intermediate patterns of the endometrium were not significantly different in the two groups. The echogen patterns of the endometrium were significantly higher in control group (p<0.0001). Finally, implantation rate and the chemical pregnancy rates were higher in the sildenafil citrate group but not significantly. Conclusion: As our study shows, the oral use of sildenafil citrate is a good way to improve the endometrial receptivity. We recommend the routine use of oral sildenafil citrate in patients with a previous failure of assisted reproduction technology cycles due to poor endometrial thickness.
ACCESSION #
96841552

 

Related Articles

  • Does thyroid-stimulating hormone influence the prognosis of patients with endometrial cancer? A multicentre trial. Seebacher, V; Hofstetter, G; Polterauer, S; Reinthaller, A; Grimm, C; Schwameis, R; Taucher, S; Wagener, A; Marth, C; Concin, N // British Journal of Cancer;7/9/2013, Vol. 109 Issue 1, p215 

    Background:Thyroid function has been suggested to interfere with tumour biology and prognosis in different cancers. The present study was performed to investigate the impact of pre-therapeutic serum thyroid-stimulating hormone (TSH) levels on the prognosis of patients with endometrial...

  • A critical evaluation of follow-up of women treated for... Gordon, A.F.; Owen, P. // Journal of Obstetrics & Gynaecology;Jul97, Vol. 17 Issue 4, p386 

    Determines whether follow-up of patients after treatment for endometrial carcinoma is beneficial in terms of patient survival. Subjects and methods used in the study; Distributions of diseases by stage with primary and adjuvant treatments and number of recurrences; Details of cases recurrent...

  • Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: A randomized controlled trial. Pickering, Thomas G.; Shepherd, Alexander M.M.; Puddey, Ian; Glasser, Dale B.; Orazem, John; Sherman, Nancy; Mancia, Giuseppe // American Journal of Hypertension;Dec2004, Vol. 17 Issue 12, p1135 

    Background: Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in men taking multiple antihypertensive medications in a randomized, double-blind, placebo-controlled...

  • A Double-blind Placebo-controlled Evaluation of the Effect of Topical Sildenafil on Erectile Dysfunction. Yonessi, Mehdi; Saeedi, Madjid // Journal of Applied Research;2005, Vol. 5 Issue 2, p289 

    Several adverse effects have been reported with use of oral sildenafil in the treatment of erectile dysfunction (ED). In this study, a formulation of sildenafil topical gel was compared with sildenafil tablet in a randomized, double-blind, prospective, placebo-controlled clinical trial. A total...

  • Combination therapy improves premature ejaculation. Overmyer, Mac // Urology Times;Oct2002, Vol. 30 Issue 10, p6 

    Discusses results of studies documenting the improvement of sildefanil therapy when combined with the antidepressant drug lidocaine in men suffering from premature ejaculation in the U.S. Patient characteristics; Drug dosage; Improvement in mean ejaculatory time.

  • Endometrial cancer risk in combined hormone regimens. Walling, Anne D. // American Family Physician;9/1/1997, Vol. 56 Issue 3, p957 

    Presents a summary of the work `Risk of Endometrial cancer in Relation to Use of Oestrogen Combined With Cyclic Progestagen Therapy in Postmenopausal Women,' by S. A. Beresford, et al. from `Lancet' 1997.

  • Hemodynamic Effects of Sildenafil in Men with Severe Coronary Artery Disease. Herrmann, Howard C.; Chang, Gene; Klugherz, Bruce D.; Mahoney, Paul D. // New England Journal of Medicine;06/01/2000, Vol. 342 Issue 22, p1622 

    Background: The cardiovascular effects of sildenafil are important because of the frequent presence of underlying cardiac disease in men with erectile dysfunction and reports indicating serious cardiac events temporally associated with the use of this drug. Methods: We assessed the systemic,...

  • A Controlled Trial of Sildenafil in Advanced Idiopathic Pulmonary Fibrosis.  // New England Journal of Medicine;8/12/2010, Vol. 363 Issue 7, p620 

    Background: Sildenafil, a phosphodiesterase-5 inhibitor, may preferentially improve blood flow to well-ventilated regions of the lung in patients with advanced idiopathic pulmonary fibrosis, which could result in improvements in gas exchange. We tested the hypothesis that treatment with...

  • Cardiovascular highlights from non-cardiology journals. Lindsay, Alistair // Heart;May2013, Vol. 99 Issue 10, p750 

    The article discusses outcome of clinical trials on cardiovascular diseases as published in journals not related to cardiology. It mentions that treatment using Erythropoietin did not improve the test results of the clinical trial in patients with systolic heart failure. It also reports that...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics