TITLE

Effect of acrylamide and glycyrrhizo globra on rat offspring

AUTHOR(S)
Mirjalili, A.; Dortaj, H.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p27
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Acrylamide (ACR) has been used to synthesize polyacrylamide for laboratories and monomer for industrial products. This material has been identified as a food-borne toxicant produce during the heating process of carbohydrate containing foods. In the traditional medicine Glycyrrhizo Globra (GG) used clinically for their anti-inflammatory and anti oxidant usage. The aim of this study was to evaluate morphological changes in rat offspring following administration ACR during pregnancy and lactation. Material and Method: Plug positive female Wistar rats were divided into four groups: group A: (control group); group B: (ACR administration 10 mg/kg/day orally); group C: (GG administration 150 mg/kg/day orally); group D: (ACR+GG). After 21 days of born mothers and their pups evaluate for morphological changes and the weight were measured by digital scale. The results were analyzed by SPSS software (15) and p<0.05 was considered significant. Results: The results showed that ACR treatment produce severe sign of body weight loss in both mothers and their offspring. The newborn on group ACR were hairless also food and water intake reduce in this group. Conclusion: Our findings demonstrated that prenatal and perinatal ACR induced morphological changes in developing rat and GG had protection role from these changes.
ACCESSION #
96841543

 

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