The effect of estrogen receptor a polymorphism on semen quality

Khosravifar, M.; Chekini, Z.; Yazdi, R. Salman; Azizi, M.; Gilani, M. Sadighi; Afsharian, P.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p17
Academic Journal
Introduction: Estrogens are recognized as one of the significant regulators of spermatogenesis. In the target tissue, estrogen function is mediated by estrogen receptors (ER-α or ER-β). Many studies identified some ESR) polimorphisms can affect semen parameters and etiology of male infertility. Materials and Methods: A cohort of 264 infertile men who were referred to Royan Institute was evaluated. This group was consisted of 149 Nonobstractive Azoospermia and 115 oligo- asteno- terato zoospermia and ninety fertile men were enrolled as normal controls. All patients underwent a comprehensive examination, karyotyping and molecular test for Y chromosome micro deletion. All subjects had a normal karyotype and intact Y chromosome. DNA was extracted from whole blood, and amplification of ESRt was accomplished using PCR. RFLP was applied to determine rs2234693 (ESR1 pvull OT). Statistical analysis was performed using the Chi-square test. Results: Both allele and genotype frequencies of rs2234693 were not significantly different among infertile men (Nonobstractive Azoospermia, oligo-asteno- terato zoospermia) and controls (p>0.05). Consequently, rs2234693 was not associated with semen quality. Conclusion: Estrogen plays a critical role in male reproduction system. Previous studies have shown that intron positioned within an ORF can affect gene expression. Although, in the current study, no association was found between intronic polymorphism (rs rs2234693) of ESR1 gene and semen quality. To determine whether intronic polymorphism pvull C>T of ESR1 is associated with alteration of ESRα expression in infertile men; we will investigate ESR1 gene expression in same samples with different genotypes.


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