TITLE

Correlation between women age and oocyte quality, embryo formation and pregnancy outcomes in assisted reproductive technology (ART) cycles: a retrospective analysis

AUTHOR(S)
Esmail-Abad, S. Ghasemi; Razi, M. H.; Razi, Y.; Pourmasumi, S.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: To estimate the effect of women age on assisted reproductive technology (ART) outcomes. Materials and Methods: In a retrospective study, a total of 1560 in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) cycles were initiated in different age-groups women. Patient's data including Age, number of retrieved oocytes and matured oocytes, types of ART procedures, number of fertilized oocytes, zygote and embryo scores, as well as, pregnancy and delivery rates were ascertained by records review and face-to-face follow-up. Results: The results showed a significantly negative correlation between age of patients and the number of oocytes retrieved (p<0.01), mature oocytes (p<0.001), and fertilized oocytes (p<0.01) in five age- groups. We found no significantly differences in the number of mature oocytes in the 26-30 age group with the women who aged between 31 and 35 (p=0.066). The zygote and embryo scores only showed a significant negative correlation with age in women more than 40 years of age (p<0.01 for each). However, a statistically negative correlation was found between the age of women with clinical pregnancy and delivery rates (p=0.031 and p=0.006, respectively). No striking differences found in pregnancy rate between IVF and ICSI procedures (p=0.095 and p=0.117, respectively). Conclusion: The women age negatively influences outcome of assisted reproductive technology treatment.
ACCESSION #
96841501

 

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