TITLE

Effects of prednisolone on pregnancy outcomes among infertile patients undergoing intra cytoplasmic sperm injection (ICSI)

AUTHOR(S)
Nanbakhsh, F.; Ilkhanizadeh, B.; Moghadasian, N.; Oshnouei, S.; Kiarang, N.; Asadi, N.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p9
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Regarding the develops of treatment and management of infertility during recent three decades, success of these methods is limited, due to explaining of autoimmune mechanisms in unsuccessful outcomes in ICSI cycles, glucocorticoids may be could get better success in ICSI cycles by reduction of immune cells in uterus and blood circulation of patients. Therefore this study tried to show how corticosteroid therapy improves the results of ICSI. Materials and Methods: This randomized clinical trial study was included infertile women were candidate for ICSI in Kosar infertility center- urmia medical sciences university between 2011-2013. 134 patients equally were divided to the study. Prednisolone get started from one day before embryo transfer, 20 mg/daily to 7 days and continued with 10 mg/daily for next 7 days. The day of 15 after transfer Prednisolone was stopped. On the 16 days after transfer pregnancy test were did and positive results were followed on 6 weeks and monthly. Results: In prednisolone group, 32 (47.8%) had chemical pregnancy vs. 32 (47.8%) in control group. Clinical pregnancy rate was 28(41.8%) and 22(32.8 %) of prednisolone vs. control group, blighted ovum were 2 (6.7%) and 4 (15.4%) in trial vs. control group. Abortion was 4 (13.3 %) in prednisolone group and 7 (26.9%) in control group. In all results there was no significant difference between two groups (p>0.05). Conclusion: Prednisolone improved pregnancy outcomes including chemical pregnancy, appearance of fetus heart and abortion before 20 weeks but there was no significant difference between two groups.
ACCESSION #
96841497

 

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