Antioxidant and estrogen combination in induction ovulation of infertile women

Jahromi, A. Rasekh; Maalhagh, M.; Alipour, F.; Pad, N.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p7
Academic Journal
Introduction: Many studies reported that antioxidants such as vitamin E, vitamin C help to scavenge the oxygen radicals throughout the female reproductive tract that might improve the infertility treatment. The aim of this research is adjusted a regimen that is a combination of antioxidant and ovulation induction drugs and evaluation of pregnancy rate. Materials and Methods: This is a clinical study which was done on 101 infertile women that referred to Dr. Rasekh clinic in Jahrom city. Results are reported as number and percentage and the Chi-square test .All these patients were treated with regimen include letrozole+ tamoxifen+ estrogen+ Vitamin E. Most of the women in this study were in range of 20-30 years old (63.4%). 24.8% of patients were case of PCO syndrome. Frequency of pregnancy was reported based on endometrial quality, endometrial thickness and follicular size. Data was analyzed by SPSS. Results: At the end of the study 25.7% of patients treated with this regimen were pregnant. 44.6%) of follicular sizes were more than 18 mm. 68.7% of patients had high quality of endometrium (triple layer & lucid). 71.6%o of endometrial thickness was more than 8 mm. Conclusion: Based on the results of this study, this regimen can improve the endometrial quality and thickness which are required for successful implantation of fetus in uterus. Also this regimen had acceptable effects on follicular size which is one of the basic steps in success of ovulation induction. Pregnancy was occurred in 1 woman between 4 infertile women. Another important factor; availability of drugs, low cost.


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