TITLE

The role of heparin on embryo implantation rate in recurrent implantation failure cases without history of thrombophilia

AUTHOR(S)
Hamdi, K.; Danaii, S.; Ghasemzadeh, A.; Farzadi, L.; Abdollahi, S.; Nouri, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p6
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The causes of recurrent implantation failure (RIF) in patients treated with assisted reproductive techniques (ART) are unknown. Several studies have shown the improving effect of heparin on the outcome of ART. Moreover, it has been reported adding heparin in non-thrombophilia patients with RIF is useful probably for its anti-inflammatory effects. Therefore, the aim of this study was to evaluate the beneficial effects of heparin on ART outcomes in women with history of RIF and without history of congenital or acquired thrombophilia in a randomized, controlled clinical trial (RCT). Materials and Methods: in this study, 100 patients with a history of two or more failures in implantation in cycles of ART were randomly subdivided into two groups of study and control. Patients of the control group just received the luteal phase support. In the patients of study group, in addition to the routine support of luteal phase 5000 units of subcutaneous heparin were administered for 15 days from the day of oocyte pick up. Pregnancy test (β-HCG) was done 15 days after embryo transfer. Results: In the study group, (β-HCG was positive in 16 (32%) patients and negative in 34 (68%). In the control group, (β-HCG was positive in 15 (30%) patients and negative in 35(70%). There was no significant difference between two groups for the pregnancy rate (P=0.5). Conclusion: Although the effect of heparin on pregnancy was not statistically significant in this study, with regard to the numerous benefits of this agent, it is recommended to study its effects in further studies with more samples.
ACCESSION #
96841488

 

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