Two protocols for pretreatment in women with polycystic ovary syndrome before intracytoplasmic sperm injection cycle; a prospective, randomized, clinical trial

Pourmatroud, E.; Mohammad Jafari, R.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p4
Academic Journal
Introduction: The aim of this study was to compare the effectiveness of metformin with simvastatin administration prior to ICSI in patients with PCOS. Materials and Methods: In this clinical trial, the efficacy of these drugs in 40 women with PCOS (20 patients in each group; A: simvastatin and B: metformin) who were candidates for ICSI were evaluated. In both groups, the drug was administered for eight weeks before starting the ICSI cycle. Endocrine, metabolic and clinical parameters were measured before and after drug therapy; in addition, the results of the ICSI cycle were evaluated in both groups. Results: The results showed that both drugs significantly improved patients' hirsutism scores, and that simvastatin had a greater effect than metformin (Group A; d=0.0001 vs. Group B; p=0.003). Simvastatin reduced some biochemical parameters, such as FSH, LH, testosterone, total cholesterol, and LDL, and significantly increased the HDL levels, whereas metformin significantly decreased FSH, TG, testosterone and total cholesterol. Overall, 35% and 30% of patients treated with metformin and simvastatin, respectively, became pregnant. There was no significant difference between the effects of these two drugs on the ICSI cycle results, such as the number of oocytes in meiosis 2 (M2) phase (p=0.4) and the number of grade A embryos (p=0.7). Conclusion: The results showed that simvastatin effectively improved hyperandrogenism signs and symptoms in PCOS patients, but the impressive effects of simvastatin as a pretreatment regimen were not significantly different from metformin with regards to ICSI cycle outcome.


Related Articles

  • GRIEF GLOSSARY.  // Women's Health;Nov2014, Vol. 11 Issue 9, p150 

    The article enumerates the most common female reproductive organ diseases, including polycystic ovary syndrome, endometriosis and sexually-transmitted infections.

  • Expression of molecules associated with tissue homeostasis in secretory endometria from untreated women with polycystic ovary syndrome. C. Avellaira; A. Villavicencio; K. Bacallao; F. Gabler; P. Wells; C. Romero; M. Vega // Human Reproduction;Dec2006, Vol. 21 Issue 12, p3116 

    BACKGROUND: The hormonal alterations observed in women with polycystic ovary syndrome (PCOS) may promote implantation failure as well as disruption of their endometrial homeostasis. To evaluate cell survival of mid-secretory endometrium from untreated women with PCOS, we measured the expression...

  • Anti-mullerian and androgens hormones in women with polycystic ovary syndrome undergoing IVF/ICSI. Swellam, Menha; Khaial, Abeer; Mosa, Tamer; El-Baz, Hatim; Said, Mohamed // Iranian Journal of Reproductive Medicine;Nov2013, Vol. 11 Issue 11, p883 

    Background: Despite its frequency, the polycystic ovary syndrome (PCOS) is still a difficult diagnosis in endocrinology, gynecology, and reproductive medicine. The Rotterdam consensus conference proposed to include the ultrasonographic follicle count as a new diagnostic criterion. Unfortunately,...

  • Elevated Serum Advanced Glycation End-Products.  // Fertility Weekly;12/22/2008, p3 

    The article reports on the study which examined whether elevated advanced glycation end-product (AGE) levels in non-insulin resistant polycystic ovary syndrome (PCOS) patients is a distinct finding compared to those presenting the isolated components of the syndrome and in PCOS subphenotypes....

  • Epigenetic Alterations in the X Chromosome Influences Susceptibility.  // Fertility Weekly;11/6/2006, p3 

    The article reports on the findings of the study on the influence of X chromosome inactivation on the development of polycystic ovary syndrome (PCOS) in patients in Australia and in the U.S. The study indicates that the inactivation of the X chromosome is influential in the development of some...

  • Trouble Down Below. Colino, Stacey // Women's Health;Jan/Feb2011, Vol. 8 Issue 1, p68 

    The article offers information on the symptoms, diagnosis and treatments for five gynecological disorders. They include endometriosis, which can result in cramps, painful sex, diarrhea or constipation and doubles the risk of infertility, polycystic ovarian syndrome (PCOS) which causes irregular...

  • WNT4 Signaling in Female Gonadal Development. Pellegrino, Miriam; Maiorino, Raffaella; Schonauer, Sergio // Endocrine, Metabolic & Immune Disorders - Drug Targets;Jun2010, Vol. 10 Issue 2, p168 

    WNT4 signaling pathways represent an important step in the multi-faceted process of mammalian gonadal differentiation and the development of internal genitalia. WNT4 protein controls the cytoplasmatic stability of specific transcriptional coactivator β catenin during both embriogenesis and...

  • High Levels of TPSA Detected in Serum of Infertile Women with PCOS.  // Fertility Weekly;3/9/2009, p2 

    The article reports on the result of the study which assesses whether total prostatic specific antigen (TPSA) is an essential marker for infertile women with polycystic ovary syndrome (PCOS). The study was participated by 64 women with PCOS and 20 normoovulatory women where TPSA levels were...

  • Women with polycystic ovaries reach menopause later.  // New Scientist;6/12/2010, Vol. 206 Issue 2764, p17 

    The article discusses a report in a 2010 issue of “Human Reproduction” regarding research by scientists at Shahid Beheshti University in Iran, investigating the link between decreased fertility in young women and an increased reproduction lifespan. According to researchers, women...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics