TITLE

Two protocols for pretreatment in women with polycystic ovary syndrome before intracytoplasmic sperm injection cycle; a prospective, randomized, clinical trial

AUTHOR(S)
Pourmatroud, E.; Mohammad Jafari, R.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p4
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The aim of this study was to compare the effectiveness of metformin with simvastatin administration prior to ICSI in patients with PCOS. Materials and Methods: In this clinical trial, the efficacy of these drugs in 40 women with PCOS (20 patients in each group; A: simvastatin and B: metformin) who were candidates for ICSI were evaluated. In both groups, the drug was administered for eight weeks before starting the ICSI cycle. Endocrine, metabolic and clinical parameters were measured before and after drug therapy; in addition, the results of the ICSI cycle were evaluated in both groups. Results: The results showed that both drugs significantly improved patients' hirsutism scores, and that simvastatin had a greater effect than metformin (Group A; d=0.0001 vs. Group B; p=0.003). Simvastatin reduced some biochemical parameters, such as FSH, LH, testosterone, total cholesterol, and LDL, and significantly increased the HDL levels, whereas metformin significantly decreased FSH, TG, testosterone and total cholesterol. Overall, 35% and 30% of patients treated with metformin and simvastatin, respectively, became pregnant. There was no significant difference between the effects of these two drugs on the ICSI cycle results, such as the number of oocytes in meiosis 2 (M2) phase (p=0.4) and the number of grade A embryos (p=0.7). Conclusion: The results showed that simvastatin effectively improved hyperandrogenism signs and symptoms in PCOS patients, but the impressive effects of simvastatin as a pretreatment regimen were not significantly different from metformin with regards to ICSI cycle outcome.
ACCESSION #
96841484

 

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