TITLE

Transvaginal endometrial perfusion of granulocyte colony-stimulating factor for infertile women with thin endometrium in frozen embryo transfer program

AUTHOR(S)
Eftekhar, M.; Sayadi, M.; Arabjahvani, F.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p3
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: We often see patients with a thin endometrium in ART cycles, in spite of standard and adjuvant treatments. Improving endometrial growth in patients with a thin endometrium is very difficult. Without adequate endometrial thickness these patients, likely, would not have reached embryo transfer. Materials and Methods: This is a non randomized intervential clinical trial. Among 68 infertile patients with thin endometrium (7 mm) at the 12th-13th cycle day, 34 patients received G-CSF (300 microgram/lmL) to improve endometrial thickness. It was directly administered by slow intrauterine infusion using IUI catheter. If the endometrium had not reached at least a 7-mm within 48-72 h, a second infusion was given. Endometrial thickness was assessed by serial vaginal ultrasound at the most expanded area of the endometrial stripe. The cycle was cancelled in the patients with thin endometrium (endometrial thickness 7mm) until 19th cycle day ultimately. Results: The cycle cancelation rate owing to thin endometrium was similar in G-CSF group (15.20%), followed by (15.20%) in the control group (p=1.00). The endometrial growth was not different within 2 groups, an improvement was shown between controlled and G-CSF cotreated groups, with chemical (39.30% vs. 14.30%) and clinical pregnancy rates (32.10% vs. 12.00%) although were not significant. Conclusion: Our study fails to demonstrate that G-CSF has the potential to improve endometrial thickness but has the potential to improve chemical and clinical pregnancy rate of the infertile women with thin endometrium in frozen-thawed embryo transfer cycle.
ACCESSION #
96841479

 

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