Effect of oxytocin on serum level of luteinizing hormone in women without ovulation

Haerifar, N.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p1
Academic Journal
Introduction: Infertility is a problem that in addition to psychological effects, its high medical costs is also gripped the family and society. Regarding the role of the hormone oxytocin in stimulating ovulation and its less complications and cost, it may be considered substitutes for HCG. We decided to perform this study because the mechanism of effect of oxytocin on ovulation is not clear and no study has been conducted directly about its effect on LH surge. Materials and Methods: Of infertile women without ovulation, presenting to specialized clinics of Tabriz University of Medical Sciences, who had ovulation following excitation with clomiphene, 20 patients were selected, and 20 patients received 5 U intra-muscular oxytocin. This was "experimental" and "Case- Control" study in which the subgroups were cased for: • Ultrasound study of follicular growth and follicle diameter measurement; • Serum LH levels measured periodically in both groups; and • Ovulation confirming using serum progesterone measurement in the middle of the luteal phase. The data obtained in the groups were analyzed by SPSS software version 15 using T-Case. Results: The mean serum LH levels after 24 h was 21.87±21.71 mIu/ml in Control group and 23.77±34.51 mIu/ml in Case group, without significant difference (p=0.836); but u-man- Whitney Case showed significant difference (p=0.029) of mid-luteal average serum progesterone between the Controls (15.92 ng/ml) and the group (23.88 ng/ml). Conclusion: Although there was no significant difference in the mean serum LH after 24 h in two groups, but the presence of significant difference in mean mid- luteal progesterone levels in both groups suggest that administration of oxytocin is effective in the Ovulation induction.


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