TITLE

Effects of cytotoxic agents on gonadal function in adult men

AUTHOR(S)
Molaie, M.; Jafarzadeh, H.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Approximately 15% men with newly diagnosed cancer are younger than 55 yr at the time of diagnosis, among them about 26% of them are <20 yr old. Around 24,000 new cases of testicular cancer are diagnosed every year in Europe. It is the most common cancer in men younger than 45 yr, accounting for 17% of all cancers occurring men below that age. Today high percentage of these patients is cured by using chemotherapy, radiation, or the combination. Due to their age, family planning has often not started yet. Hence, fertility and sexual functioning are key issues for these patients. The aim was to evaluate kind of chemotherapeutic agents with the most deleterious effect on male fertility. Materials and Methods: This article is result of newest review and original articles. We searched in PubMed, Elsevier, update, etc. Results: The mechanism action of most cytotoxic chemotherapeutic agents is interference with obligatory cell processes, such as DNA synthesis, in the rapidly dividing cancer cells. In testis, cells within seminiferous tubules of germinal epithelium have the highest mitotic and meiotic indices, and are most vulnerable the toxic effects of chemotherapy. Conclusion: Cancer treatment has become more successful during the last few decades; increasing attention must now be focused on improving quality of life in these patients. Number of strategies has been explored to preserve fertility in men scheduled to receive cytotoxic chemotherapy such as semen cryopreservation and hormonal manipulation.
ACCESSION #
96841474

 

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