Effects of cytotoxic agents on gonadal function in adult men

Molaie, M.; Jafarzadeh, H.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p1
Academic Journal
Introduction: Approximately 15% men with newly diagnosed cancer are younger than 55 yr at the time of diagnosis, among them about 26% of them are <20 yr old. Around 24,000 new cases of testicular cancer are diagnosed every year in Europe. It is the most common cancer in men younger than 45 yr, accounting for 17% of all cancers occurring men below that age. Today high percentage of these patients is cured by using chemotherapy, radiation, or the combination. Due to their age, family planning has often not started yet. Hence, fertility and sexual functioning are key issues for these patients. The aim was to evaluate kind of chemotherapeutic agents with the most deleterious effect on male fertility. Materials and Methods: This article is result of newest review and original articles. We searched in PubMed, Elsevier, update, etc. Results: The mechanism action of most cytotoxic chemotherapeutic agents is interference with obligatory cell processes, such as DNA synthesis, in the rapidly dividing cancer cells. In testis, cells within seminiferous tubules of germinal epithelium have the highest mitotic and meiotic indices, and are most vulnerable the toxic effects of chemotherapy. Conclusion: Cancer treatment has become more successful during the last few decades; increasing attention must now be focused on improving quality of life in these patients. Number of strategies has been explored to preserve fertility in men scheduled to receive cytotoxic chemotherapy such as semen cryopreservation and hormonal manipulation.


Related Articles

  • Testicular Cancer: An Overview. Brown, Carlton Gene // MEDSURG Nursing;Feb2003, Vol. 12 Issue 1, p37 

    Presents an overview of the treatment, side-effect management and other issues related to testicular cancer (TC). Incidence of TC in the U.S.; Signs and symptoms; Delineation of stage and disease involvement; Treatment and survival rates of men diagnosed with TC.

  • Doctor … Will I Still Be Able To Have Children? Saxman, Scott // JNCI: Journal of the National Cancer Institute;11/2/2005, Vol. 97 Issue 21, p1557 

    Discusses various aspects related to testicular cancer. Occurrence of testicular cancer before or during the peak reproductive period of life in men; Effect of testicular cancer and its associated therapy on fertility; Application of aggressive therapy on testicular cancer.

  • Neck mass as the first presentation of testicular choriocarcinoma. Ahmadi, Sayed Ali; Tavakoli, Hassan; Samadi, Nasrin // European Archives of Oto-Rhino-Laryngology;Mar2006, Vol. 263 Issue 3, p290 

    Choriocarcinoma is a highly malignant tumor of the testis and usually occurs as a component of mixed germ cell tumor. The testicular enlargement may be subtle, and the patient may present with metastasis, the neck being one of its least reported locations. A case of testicular choriocarcinoma in...

  • Citations and Clinicians' Notes: Testicular Cancer.  // Current Medical Literature: Urology;2003, Vol. 9 Issue 4, p113 

    Presents citations and clinicians' notes on testicular cancer. Management of stage I seminoma of the testis; Development of second primary testicular cancer; Gonadal hormones in long-term survivors after treatment for unilateral testicular cancer.

  • Surgical Management of Testicular Cancer. Stevenson, Tara D.; McNeill, Jeanette // Clinical Journal of Oncology Nursing;Aug2004, Vol. 8 Issue 4, p355 

    Provides information on the surgical management of testicular cancer. Number of new cases of testicular cancer that occurred in 2003; Etiology of the disease; Factors associated with an increased risk of developing testicular cancer.

  • Survival from testicular cancer in England and Wales up to 2001. Nur, U.; Rachet, B.; Mitry, E.; Cooper, N.; Coleman, M. P. // British Journal of Cancer;9/2/2008 Supplement, Vol. 99, pS80 

    The article presents an analysis on survival from testicular cancer up to 2001 in England and Wales. This malignant disease has relative increased incidence in men under 50 years of age living in these countries. It examined survival patterns for 18,605 men diagnosed with testicular cancer aged...

  • Unilateral Malignant Leydig Cell Tumor of Testis in a Patient With Contralateral Cryptorchidism. Efthimiou, Ioannis; Mamoulakis, Charalampos; Papageorgiou, George; Kazoulis, Sabbas; Prevedorou, Despina; Kontogiorgos, George; Christoulakis, Ioannis // Urology Journal;Jan2009, Vol. 6 Issue 1, p60 

    The article presents a case study of a 72-year-old man suffering from unilateral malignant Leydig cell tumor (LCT) of testis. The man had a history of contralateral cryptorchidism. Physical examination showed a hard and swollen left testis. Ultrasonography revealed the presence of a...

  • Facilitators and obstacles to sperm banking in young men receiving gonadotoxic chemotherapy for cancer: the perspective of survivors and health care professionals. Marie A. Achille; Zeev Rosberger; Roxane Robitaille; Sophie Lebel; Jean-Philippe Gouin; Barry D. Bultz; Peter T.K.Chan // Human Reproduction;Dec2006, Vol. 21 Issue 12, p3206 

    BACKGROUND: Testicular cancer and Hodgkin’s disease are among the most common malignancies to affect young men of reproductive age. Although both are associated with high rates of infertility, sperm banking (SB) remains underutilized by both diagnostic groups. Reasons for this remain...

  • Risk of Contralateral Testicular Cancer: A Population-based Study of 29515 U.S. Men. Fossá, Sophie D.; Jinbo Chen; Schonfeld, Sara J.; McGlynn, Katherine A.; McMaster, Mary L.; Gail, Mitchell H.; Travis, Lois B. // JNCI: Journal of the National Cancer Institute;7/20/2005, Vol. 97 Issue 14, p1056 

    Background: Although risk estimates for synchronous and metachronous contralateral testicular cancers vary widely, many clinicians recommend routine biopsy of the contralateral testis for patients diagnosed with unilateral testicular cancer. We evaluated the risk of contralateral testicular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics