March 2012
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi;2012 Special Issue, Vol. 37 Issue S1, p220
Academic Journal
Aim: Chaperones of intracellular lipid known as FABP (fatty acid-binding protein) is a molecule regulating the lipid response in cells and as well as associated with inflammatory and metabolic pathways. H-FABP (heart-type fatty acid-binding protein) is abundant in myocyte and released into circulation rapidly from cardiomyocytes in cell damage. We aimed to determine the level of serum H-FABP as a marker of myocardial damage in patients with high procalcitonin levels. Methods: 26 patients with high procalcitonin and 25 healthy were included in the study. Serum H-FABP levels were measured using ELISA in both group. Results: Serum H-FABP levels were significantly (P=0,026) higher in patients than that of the control group. There was a significant positive correlation between procalcitonin and H-FABP levels in the patients group. Conclusion: It was observed that serum H-FABP levels as a marker of damage were also rise in patients with high procalcitonin. We think that H-FABP levels may be a biochemical marker in the evaluation of organ damage in sepsis.


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