Mean corpuscular volume (MCV) as a marker for 6-MMP and 6-TG, the toxic and active metabolites of 6-mercaptopurine (6-MP)

Ahdoot, Allen; Tobak, Julie; Gotian, Amnon; Noyer, Charles; Brandt, Lawrence
September 2003
American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS240
Academic Journal
An abstract of the article concerning mean corpuscular volume (MCV) as marker for 6-Tg and 6-MMP which are toxic and active metabolites of 6-mercaptopurine is presented.


Related Articles

  • In vitro and in vivo genotoxicity of 1,3-butadiene and metabolites Arce, G. T.; Choy, W. N.; Cunningham, M. J.; Sarrif, A. M. A. M. Sarrif; Vincent, D. R. // Environmental Health Perspectives;Jun1990, Vol. 86, p75 

    No abstract available.

  • Inhalation exposure of rats and mice to 1,3-butadiene induces N6-adenine adducts of epoxybutene... Koivisto, Pertti; Adler, Ilse-Dore // Environmental Health Perspectives Supplements;May96 Supplement 3, Vol. 104, p655 

    Reports on DNA binding of butadiene monoepoxide, a first metabolite of 1,3-butadiene catalyzed by monooxygenases. Materials and methods; Structures of butadiene monoxide purine adducts; Interfering products.

  • A pharmacokinetic model to study the excretion of trichloroethylene and its metabolites after an inhalation exposure Murayama, N.; Fujiwara, Y.; Sato, A.; Nakajima, T. // British Journal of Industrial Medicine;Feb1977, Vol. 34 Issue 1, p56 

    No abstract available.

  • Effects of chlorphenamidine and its metabolites on HeLa cells Murakami, M.; Fukami, J. // Bulletin of Environmental Contamination & Toxicology;Feb1974, Vol. 11 Issue 2, p184 

    No abstract available.

  • A simplified analysis of [18F]3′-deoxy-3′-fluorothymidine metabolism and retention. Shields, Anthony F.; Briston, David A.; Chandupatla, Samatha; Douglas, Kirk A.; Lawhorn-Crews, Jawana; Collins, Jerry M.; Mangner, Thomas J.; Heilbrun, Lance K.; Muzik, Otto // European Journal of Nuclear Medicine & Molecular Imaging;Apr2007, Vol. 34 Issue 4, p613 

    A correction to the article "A Simplified Analysis of [18F]3'-deoxy-3'-Fluorothymidine Metabolism and Retention" that was published in the January 9, 2007 issue is presented.

  • Towards quantitative metabolome analysis. Stein, Nadine; Zeller, Tina; Oldiges, Marco // BMC Systems Biology;2007 Supplement 1, Vol. 1, p1 

    An abstract of the article "Towards quantitative metabolome analysis," by Nadine Stein, Tina Zeller and Marco Oldiges is presented.

  • Analysis of metabolome data by a maximum likelihood approach. Choi, Claudia; Hundertmark, Claudia; Thielen, Bernhard; Benkert, Beatrice; Münch, Richard; Schobert, Max; Schomburg, Dietmar; Jahn, Dieter; Klawonn, Frank // BMC Systems Biology;2007 Supplement 1, Vol. 1, pP20 

    An abstract of the article "Analysis of metabolome data by a maximum likelihood approach," by Claudia Choi, Claudia Hundertmark, Bernhard Thielen, Beatrice Benkert, Richard Münch, Max Schobert, Dietmar Schomburg, Dieter Jahn and Frank Klawonn is presented.

  • corepressor:. Schlegel, Rolf H. J. // Encyclopedic Dictionary of Plant Breeding & Related Subjects;2003, p108 

    An encyclopedia entry for the term "corepressor," which refers to a metabolite that in conjugation with a repressor molecule binds to the operator gene present in an operon and prevents the synthesis of a repressible enzyme, is presented.

  • Amifostine (WR-2721) selective protection against melphalan genotoxicity. Buschini, A; Anceschi, E; Carlo-Stella, C; Regazzi, E; Rizzoli, V; Poli, P; Rossi, C // Leukemia (08876924);Sep2000, Vol. 14 Issue 9, p1642 

    Amifostine (WR-2721) is an aminothiol compound dephosphorylated at the tissue site by alkaline phosphatase to the active metabolite, which is able to inactivate electrophilic substances and scavenge free radicals. Amifostine effects against melphalan-induced DNA strand breaks were studied in...

  • Hepatic Disposition of Electrophilic Acyl Glucuronide Conjugates. Sallustio, B.C.; Sabordo, L.; Evans, A.M.; Nation, R.L. // Current Drug Metabolism;Sep2000, Vol. 1 Issue 2, p163 

    Acyl glucuronides are a unique class of electrophilic metabolites, capable of non-enzymatic reactions including acylation and/or glycation of endogenous macromolecules, hydrolysis to reform the parent aglycone, and intra-molecular rearrangement. Three human UDP-glucuronosyltransferases (UGTs)...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics