Effects of the combination of PEG-interferon alpha-2B and ribavirin on the inflammation and fibrosis scores of patients with chronic hepatitis C infection who were virologic non-responders to interferon alpha-2B and ribavirin

Hassanein, Tarek I; Barakat, Fatma M; Behling, Cynthia; Myers, Wendy Y; D. Carlson, Meghan; Chatfield, Eileen R; Selim, Khaled M
September 2003
American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS103
Academic Journal
An abstract of the article "Effects of the Combination of PEG-interferon Alpha-2B and Ribavirin on the Inflammation and Fibrosis Scores of Patients With Chronic Hepatitis C Infection Who Were Virologic Non-responders to Interferon Alpha-2B and Ribavirin" by Wendy Y. Myers and colleagues is presented.


Related Articles

  • Arylpiperazines with Affinity Toward a1-Adrenergic Receptors. Manetti, F.; Corelli, F.; Strappaghetti, G.; Botta, M. // Current Medicinal Chemistry;Jul2002, Vol. 9 Issue 13, p1303 

    In the last years, a1 adrenoceptors (a1-AR) have been the subject of intense research, in part because receptor-binding studies and molecular biology have opened up new aspects of understanding but also because of the potential to find new drugs possibly acting toward pathophysiological...

  • The mechanism of action of α[sub 2] adrenoceptor blockers as revealed by effects on open field locomotion and escape reactions in the shuttle-box. Haller, J.; Makara, G. B.; Pintér, I.; Gyertyán, I.; Egyed, A. // Psychopharmacology;1997, Vol. 134 Issue 2, p107 

    Abstract The precise mechanism of action of alpha[sub 2] adrenoceptor blockers is not known, although in principle they have two main effects: (i) they stimulate the norepinephrinergic system by inhibiting the negative feed back of norepinephrine release (presynaptic effect) and (ii) they...

  • The involvement of α[sub 2] -adrenoceptors in the anticonvulsive effect of swim stress in mice. Peričić, Danka; Švob, Dubravka; Jazvinšćak Jembrek, Maja; Mirković Kos, Kety // Psychopharmacology;2001, Vol. 158 Issue 1, p87 

    Rationale: Various studies have shown that stressful manipulations in rats and mice lower the convulsant potency of GABA-related, but also some GABA-unrelated convulsants. The mechanism of this anticonvulsive effect of stress is still unknown. Objectives: We tested the possible involvement of...

  • Silodosin Capsules (Rapaflo). Elliott, William T.; Chan, James // Internal Medicine Alert;12/29/2008, Vol. 30 Issue 24, p190 

    The article reports on the approval of Silodosin, a highly selective alpha-1 adrenergic receptor antagonist use for the treatment of benign prostatic hyperplasia (BPH), by the U.S. Food and Drug Administration (FDA).

  • Adrenoceptor pharmacology: How the ligand changed its spots. Smith, Adam // Nature Reviews Drug Discovery;Aug2002, Vol. 1 Issue 8, p569 

    Reports that the activity of a dexefaroxan analog ligand RX 831003 at alpha[sub 2A]-adrenoceptors expressed in cultured cells depended on the nature of the co-expressed Galpha-protein subunits. Behavior of partial inverse agonist; Complexes formed by receptors and G proteins in vivo.

  • Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum. Saenz de Tejada, I; Kim, N N; Goldstein, I; Traish, A M // International Journal of Impotence Research;2000 Supplement 1, Vol. 12 Issue 1, pS20 

    The neurotransmitters and vasoactive substances regulating tone in the smooth muscle of the penile arteries/arterioles and the trabeculae of the corpora cavernosa are critical mediators of the state of penile erection. Contemporary research reveals a coordinated, intricate interplay between the...

  • Cerebral glucose metabolic and plasma catecholamine responses to the α[sub 2] adrenoceptor antagonist ethoxyidazoxan given to healthy volunteers. Schmidt, Mark E.; Oshinsky, R. Joan; Kim, Hyung-Gun; Schouten, Jennifer L.; Folley, Bradley S.; Potter, William Z. // Psychopharmacology;1999, Vol. 146 Issue 2, p119 

    Abstract Rationale: Methods that test for the central effects of alpha[sub 2]-adrenoceptor antagonists can facilitate the clinical development of such compounds. Recently we evaluated the effects of idazoxan (IDX), an alpha[sub 2]-adrenoceptor antagonist with high affinity for imidazoline sites,...

  • Direct Binding Studies of Adrenergic Receptors: Biochemical, Physiologic, and Clinical Implications. Lefkowitz, Robert J. // Annals of Internal Medicine;Sep79, Vol. 91 Issue 3, p450 

    Presents information on a study which investigated the alpha- and beta-adrenergic receptors for catecholamines in a wide variety of tissues. Classification of adrenergic receptor types; Development of adrenergic radioligands; Physiologic regulation of adrenergic receptors; Clinical implications...

  • Effect of a three-amino acid deletion in the α2B-adrenergic receptor gene on long-term body weight change in Finnish non-diabetic and type 2 diabetic subjects. Sivenius, K; Lindi, V; Niskanen, L; Laakso, M; Uusitupa, M // International Journal of Obesity & Related Metabolic Disorders;Nov2001, Vol. 25 Issue 11, p1609 

    BACKGROUND AND OBJECTIVE: The short form (Glu[sup 9]/Glu[sup 9]) of the 12Glu9 deletion polymorphism of the α[sub 2B]-adrenergic receptor gene was previously found to be associated with reduced basal metabolic rate in obese subjects. We investigated the effects of this polymorphism on changes...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics