TITLE

Role of Transforming Growth Factor-Beta Signaling Modulators in Periodontal Disease

AUTHOR(S)
Bains-Dahia, S.; Gauldie, J.; Häkkinen, L.; Larjava, H
PUB. DATE
April 2011
SOURCE
UBC Medical Journal;Apr2011, Vol. 2 Issue 2, p25
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Transforming growth factor beta 1 (TGF-β1) plays a crucial role in protection of many organs from inflammation. TGF-β1 is expressed as a latent cytokine and needs to be activated for function. Epithelial integrin avβ6 and thrombospondin-1 (TSP-1) serve as activators of TGF-β1. Mice deficient of β6 integrin (β6-/-) develop periodontal disease with apical migration of junctional epithelium, inflammation and bone loss. The aim of the present investigation was to find out whether TSP-1 jointly with avβ6 integrin participates in TGF-β1 activation and protection of periodontium from inflammation. In addition, we hypothesized that the TGF-β1-mediated immunoprotection is mediated via Smad3, a key signalling molecule in the TGF- beta;1 pathway.
ACCESSION #
62855500

 

Related Articles

  • Transforming Growth Factor-Beta and the Kidney: What We Know and What We Can Do? Hai-Chun Yang; Yiqin Zuo; Fogo, Agnes B. // Current Enzyme Inhibition;Jul2010, Vol. 6 Issue 2, p87 

    Transforming growth factor-� (TGF-�) and its receptors are expressed in the kidney. The effects of TGF-� are mainly through activation of Smad pathways. In different pathophysiological situations such as development, immunomodulation, fibrosis and cell response, TGF-�...

  • Age-dependent decrease in serum transforming growth factor (TGF)-beta 1 in healthy Japanese individuals; population study of serum TGF-beta 1 level in Japanese. Okamoto, Yoshihiro; Gotoh, Yoshimitsu; Uemura, Osamu; Tanaka, Soichi; Ando, Tsunesaburo; Nishida, Mikio // Disease Markers;2005, Vol. 21 Issue 2, p71 

    Transforming growth factor-beta1 (TGF-β1), a multi-functional cytokine, is involved in regulating a variety of cellular activities and the serum/plasma TGF-β1 level is altered with various diseases. However, most published reports have described adult patients, and so we investigated the...

  • Mechanisms of TGF-β-mediated apoptosis. Schuster, Norbert; Krieglstein, Kerstin // Cell & Tissue Research;Jan2002, Vol. 307 Issue 1, p1 

    Transforming growth factor-beta (TGF-β) is a multifunctional cytokine, whose numerous cell and tissue activities include cell-cycle control, the regulation of early development, differentiation, extracellular matrix formation, hematopoesis, angiogenesis, chemotaxis, immune functions, and the...

  • Arkadia enhances nodal-related signalling to induce mesendoderm. Niederlander, Christiane; Walsh, James J.; Episkopou, Vasso; Jones, C. Michael // Nature;4/12/2001, Vol. 410 Issue 6830, p830 

    Presents a study to investigate the function of Arkadia and its role in establishing Spemann's organizer. How the nuclear protein Arkadia specifically potentiates the mesendoderm-inducing activity of a subset of transforming growth factor (TGF)-beta family members; Identification of Arkadia as...

  • Matrix control of transforming growth factor-β function. Horiguchi, Masahito; Ota, Mitsuhiko; Rifkin, Daniel B. // Journal of Biochemistry;Oct2012, Vol. 152 Issue 4, p321 

    The cytokine transforming growth factor-beta (TGF-β) has multiple effects in both physiological and pathological conditions. TGF-β is secreted as part of a tripartite complex from which it must be released in order to bind to its receptor. Sequestration of latent TGF-β in the...

  • Integrins Modulate Cellular Fibrogenesis at Multiple Levels: Regulation of TGF-β Signaling. Hayashida, Tomoko // Endocrine, Metabolic & Immune Disorders - Drug Targets;Dec2010, Vol. 10 Issue 4, p302 

    No abstract available.

  • New insights into the role of VIP on the ratio of T-cell subsets during the development of autoimmune diabetes. Jimeno, Rebeca; Gomariz, Rosa P.; Gutiérrez-Cañas, Irene; Martínez, Carmen; Juarranz, Yasmina; Leceta, Javier // Immunology & Cell Biology;Oct2010, Vol. 88 Issue 7, p734 

    Type I diabetes is an autoimmune T-cell-mediated disease associated with overexpression of inflammatory mediators and the disturbance of different T-cell subsets. Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent with regulatory effects on activated T cells. As the...

  • TGF-Beta Blockade Increases Renal Inflammation Caused by the C-Terminal Module of the CCN2. Rodrigues-Díez, Raquel; Rayego-Mateos, Sandra; Orejudo, Macarena; Aroeira, Luiz Stark; Selgas, Rafael; Ortiz, Alberto; Egido, Jesús; Ruiz-Ortega, Marta // Mediators of Inflammation;5/5/2015, Vol. 2015, p1 

    The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF-β is considered the main fibrogenic cytokine; however, in...

  • Post-Transcriptional Regulation of Transforming Growth Factor Beta-1 by MicroRNA-744. Martin, John; Jenkins, Robert H.; Bennagi, Rasha; Krupa, Aleksandra; Phillips, Aled O.; Bowen, Timothy; Fraser, Donald J. // PLoS ONE;2011, Vol. 6 Issue 10, p1 

    Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological processes including cancer and progressive tissue fibrosis. TGF-β1 is post-transcriptionally regulated, but the underlying mechanisms...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics