Does toluidine blue detect more oral cancer?

Richards, Derek
December 2010
Evidence-Based Dentistry;Dec2010, Vol. 11 Issue 4, p104
Academic Journal
DesignA randomised controlled trial.Intervention28,167 individuals aged 15 years or older who were invited participate in a screening programme, 17,890 who lacked oral habits such as cigarette smoking or chewing betel quid were excluded leaving 10,277 eligible individuals. Of these, 2,302 refused to participate leaving a sample of 7,975 for randomisation. The test group gargled with toluidine blue solution while the control group was given a placebo dye of the same colour. Each participant was visually examined by one of six dentists with additional training. The presence of any visible lesion in the oral cavity (e.g. abnormal mucosal lesions related to OPMLs and other suspected lesions such as lichen planus, oral ulcer, hyperkeratosis, candidiasis, etc) was recorded as screen-positive. The screen-positive participants to a specialist were referred to a specialist for a definite clinical diagnosis within 10 to 14 days, to reduce false-positivity, and biopsies were arranged if oral lesions were present. The occurrence of oral cancer, survival status, and causes of death of the studied participants for the entire cohort was obtained from the National Cancer Registry and the National Household Registry until the end of 2004.Outcome measureThe number of oral lesions, premalignant or not.ResultsIn the test group 389 (9.5%) individuals had a positive screen compared with 322 (8.3%) in the control group. Two oral cancers were identified out of those with a positive screen presenting (n=320) for the referral examination from the test group with three oral cancers out of the 293 in those who complied in the control group. There were three oral cancers ascertained by the end of the follow-up among the screen-negatives in each arm (test and control) by the end of the followup period. The numbers of OPMLs in each arm of the study are shown in Table 1.ConclusionsWe demonstrated that using toluidine blue as an adjunctive tool for visual screening can detect significantly more oral submucous fibrosis and slightly more leukoplakia among high-risk individuals with habits of cigarette smoking or betel quid chewing as compared with visual screening alone.


Related Articles

  • Fluoride varnish may improve white spot lesions. Stafford, Gary L. // Evidence-Based Dentistry;Dec2011, Vol. 12 Issue 4, p104 

    DesignA randomised, parallel-group, controlled clinical trial.InterventionThe test group had fluoride varnish applied onto the tooth surfaces with WSLs using a miniature cotton swab or brush and advised not to brush for four hours. The control group had saline solution applied.Outcome...

  • More randomised controlled studies in speech and language therapy. Carding, Paul; Hillman, Robert // BMJ: British Medical Journal (International Edition);9/22/2001, Vol. 323 Issue 7314, p645 

    Editorial. Focuses on the use of randomised controlled trials in evaluating the efficacy of speech and language therapy. Past reluctance to perform randomised controlled trials of the treatment; Difficulty of applying randomised controlled studies to behavioural therapies because of...

  • A randomised multicentre trial of acupuncture in patients with seasonal allergic rhinitis - trial intervention including physician and treatment characteristics. Ortiz, Miriam; Witt, Claudia M.; Binting, Sylvia; Helmreich, Cornelia; Hummelsberger, Josef; Pfab, Florian; Wullinger, Michael; Irnich, Dominik; Linde, Klaus; Niggemann, Bodo; Willich, Stefan N.; Brinkhaus, Benno // BMC Complementary & Alternative Medicine;2014, Vol. 14 Issue 1, p1 

    Background In a large randomised trial in patients with seasonal allergic rhinitis (SAR), acupuncture was superior compared to sham acupuncture and rescue medication. The aim of this paper is to describe the characteristics of the trial's participating physicians and to describe the trial...

  • CONSORT 2010 Statement: Updated Guidelines for Reporting Parallel Group Randomised Trials. Schulz, Kenneth F.; Altman, Douglas G.; Moher, David // PLoS Medicine;Mar2010, Vol. 7 Issue 3, p1 

    The article offers information on the Consolidated Standards of Reporting Trials (CONSORT) 2010 Statement. It offers guidance for reporting all randomised controlled trials including individually randomised, two group and parallel trials. The CONSORT aims to improve the reporting of randomised...

  • Randomised controlled trials. Geddes, John // British Journal of Psychiatry;Jul2014, Vol. 205 Issue 1, p43 

    A definition of randomised controlled trials is presented.

  • Fluoride-releasing elastomerics reduce enamel decalcification during fixed appliance therapy. Kalha, Anmol S // Evidence-Based Dentistry;Dec2000, Vol. 2 Issue 4, p101 

    Objective To determine whether fluoridefreleasing elastomerics reduce enamel decalcification significantly during fixed appliance therapy. Design Randomised controlled trial. Intervention Stannous fluoride-releasing modules and chain in test group. Test and control elastomerics changes were made...

  • Linked randomised controlled trials of face-to-face and electronic brief intervention methods to prevent alcohol related harm in young people aged 14-17 years presenting to Emergency Departments (SIPS junior). Deluca, Paolo; Coulton, Simon; Alam, M. Fasihul; Cohen, David; Donoghue, Kim; Gilvarry, Eilish; Kaner, Eileen; Maconochie, Ian; McArdle, Paul; McGovern, Ruth; Newbury-Birch, Dorothy; Patton, Robert; Phillips, Ceri; Phillips, Thomas; Russell, Ian; Strang, John; Drummond, Colin // BMC Public Health;2015, Vol. 15 Issue 1, p1 

    Background: Alcohol is a major global threat to public health. Although the main burden of chronic alcohol-related disease is in adults, its foundations often lie in adolescence. Alcohol consumption and related harm increase steeply from the age of 12 until 20 years. Several trials focusing upon...

  • Intensive management of blood pressure in primary care.  // British Journal of Cardiac Nursing;Jan2013, Vol. 8 Issue 1, p11 

    An abstract of the article "Effect of intensive structured care on individual blood pressure targets in primary care: multicentre randomised controlled trial," by S. Stewart and colleagues is presented.

  • Trial shows caries reductions at one year in school-based sealant programme. Gugnani, Neeraj // Evidence-Based Dentistry;Sep2013, Vol. 14 Issue 3, p71 

    DesignPragmatic split-mouth randomised controlled trial.InterventionChildren from low-income backgrounds were randomised to have one of each first molar tooth pairs sealed. Tooth pairs were excluded when a dental sealant or dentinal caries was present on one of the teeth. Clinical examinations...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics