Acute lung injury: pathophysiology

December 2007
Thorax;Dec2007 Supp, Vol. 62, pA60
Academic Journal
The article presents abstracts on medical topics which include the induction of cyclo-oxygenase-2 by cyclic mechanical strain in human primary alveolar type 2 cells, the effect of marginated monocytes on pulmonary edema in a murine model of ventilator-induced lung injury and the role of tumor necrosis-factor (TNF)-related apoptosis inducing ligand in acute lung injury.


Related Articles

  • Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells. Futagami S; Hiratsuka T; Tatsuguchi A; Suzuki K; Kusunoki M; Shinji Y; Shinoki K; Iizumi T; Akamatsu T; Nishigaki H; Wada K; Miyake K; Gudis K; Tsukui T; Sakamoto C // Gut;Sep2003, Vol. 52 Issue 9, p1257 

    BACKGROUND: and aims: To clarify the interaction between gastric epithelial and mucosal T cells, we examined the role of cytokines released from epithelial cells in response to Helicobacter pylori water extract protein (HPWEP) in regulating T cell cyclooxygenase 2 (COX-2) expression and...

  • Monocyte chemoattractant protein 1 and macrophage cyclooxygenase 2 expression in colonic adenoma. Tanaka, S.; Tatsuguchi, A.; Futagami, S.; Gudis, K.; Wada, K.; Seo, T.; Mitsui, K.; Yonezawa, M.; Nagata, K.; Fujimori, S.; Tsukui, T.; Kishida, T.; Sakamoto, C. // Gut;Jan2006, Vol. 55 Issue 1, p54 

    Background and aims: Cyclooxygenase 2(COX-2) expression in subepithelial macrophages of colorectal adenoma has been suggested as the first in a series of steps leading to colorectal tumorigenesis. We tested the hypothesis that chemokines released from human colorectal adenoma epithelium might be...

  • Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. Dixon, Dan A.; Tolley, Neal D.; Bemis-Standoli, Kristi; Martinez, Mark L.; Weyrich, Andrew S.; Morrow, Jason D.; Prescott, Stephen M.; Zimmerman, Guy A. // Journal of Clinical Investigation;Oct2006, Vol. 116 Issue 10, p2727 

    Tight regulation of COX-2 expression is a key feature controlling eicosanoid production in atherosclerosis and other inflammatory syndromes. Adhesive interactions between platelets and monocytes occur in these conditions and deliver specific signals that trigger inflammatory gene expression....

  • COX-2 inhibition as a treatment approach in schizophrenia: Immunological considerations and clinical effects of celecoxib add-on therapy. M�ller, Norbert; Ulmschneider, Markus; Scheppach, Constanze; Schwarz, Markus J.; Ackenheil, Manfred; M�ller, Hans-J�rgen; Gruber, Rudolf; Riedel, Michael // European Archives of Psychiatry & Clinical Neuroscience;2004, Vol. 254 Issue 1, p14 

    Recent advances in immunological research regarding the differentiation between the type-1 and type-2 immune response are discussed. Increased levels of Interleukin-6 (IL-6) and the activation of the IL-6 system in schizophrenia might be the result of the activation of type-2...

  • Molecular Mechanisms of High Glucose-Induced Cyclooxygenase-2 Expression in Monocytes. Shanmugam, Narkunaraja; Gonzalo, Irene T. Gaw; Natarajan, Rama // Diabetes;Mar2004, Vol. 53 Issue 3, p795 

    The cyclooxygenase (COX)-2 enzyme has been implicated in the pathogenesis of several inflammatory diseases. However, its role in diabetic vascular disease is unclear. In this study, we evaluated the hypothesis that diabetic conditions can induce COX-2 in monocytes. High glucose treatment of...

  • Cyclooxygenase-2. Yumeng Mao; Poschke, Isabel; Kiessling, Rolf // OncoImmunology;Aug2013, Vol. 2 Issue 8, p1 

    Cyclooxygenase-2 and its product PGE2 play essential roles in inducing and maintaining the suppressive functions of MDSCs in cancer. Blockade of the COX-2/PGE2 pathway abolishes the induction of MDSCs in response to tumor-derived factors and thus may provide new opportunities for targeting MDSCs...

  • Targeting angiogenic pathway for chemoprevention of experimental colon cancer using C-phycocyanin as cyclooxygenase-2 inhibitor. Saini, Manpreet Kaur; Sanyal, Sankar Nath // Biochemistry & Cell Biology;Jun2014, Vol. 92 Issue 3, p206 

    An angiogenic pathway was studied that involved stromal tissue degradation with matrix metalloproteinases (MMPs), vesicular endothelial growth factor-A (VEGF-A), and hypoxia inducible factor-1α (HIF-1α) mediated growth regulation in a complex interaction with chemokines, such as monocyte...

  • Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification. Hou, Zhe; Falcone, Domenick J.; Subbaramaiah, Kotha; Dannenberg, Andrew J. // Carcinogenesis;May2011, Vol. 32 Issue 5, p695 

    Tumor-associated macrophages and high levels of cyclooxygenase-2 (COX-2) are associated with poor prognosis in breast cancer patients, but their potential interdependence has not been evaluated. The objective of this study was to determine whether macrophages regulate COX-2 expression in breast...

  • Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition. Lang, Stephan; Tiwari, Sanjay; Andratschke, Michaela; Loehr, Iren; Lauffer, Lina; Bergmann, Christoph; Mack, Brigitte; Lebeau, Annette; Moosmann, Andreas; Whiteside, Theresa L.; Zeidler, Reinhard // Cancer Immunology, Immunotherapy;Oct2007, Vol. 56 Issue 10, p1645 

    To determine the immunomodulatory effects of in vivo COX-2 inhibition on leukocyte infiltration and function in patients with head and neck cancer. Patients with squamous cell carcinoma of the head and neck preoperatively received a specific COX-2 inhibitor (rofecoxib, 25 mg daily) orally for 3...


Read the Article


Sign out of this library

Other Topics