International child health
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- Prevalence and molecular characterization of G6PD deficiency in two Plasmodium vivax endemic areas in Venezuela: predominance of the African A-202A/376G variant. Vizzi, Esmeralda; Bastidas, Gilberto; Hidalgo, Mariana; Colman, Laura; Pérez, Hilda A. // Malaria Journal;1/11/2016, Vol. 15, p1
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency causes acute haemolytic anaemia triggered by oxidative drugs such as primaquine (PQ), used for Plasmodium vivax malaria radical cure. However, in many endemic areas of vivax malaria, patients are treated with PQ without any...
- Glucose-stimulated and self-limiting insulin production by glucose 6-phosphatase promoter driven insulin expression in hepatoma cells. Chen, R; Meseck, M; McEvoy, R C; Woo, S L C // Gene Therapy;Nov2000, Vol. 7 Issue 21, p1802
The liver is an attractive target organ for insulin gene expression in type 1 diabetes as it contains appropriate cellular mechanisms of regulated gene expression in response to blood glucose and insulin. We hypothesize that insulin production regulated by both glucose and insulin may be...
- Plasma glucose levels are reduced in rats and mice treated with an inhibitor of glucose-6-phosphate translocase. Parker, Janice C.; VanVolkenburg, Maria A.; Levy, Carolyn B.; Martin, William H.; Burk, Suzann H.; Kwon, Younggil; Giragossian, Craig; Gant, Thomas G.; Carpino, Philip A.; McPherson, R. Kirk; Vestergaard, Pia; Treadway, Judith L.; Parker, J C; VanVolkenburg, M A; Levy, C B; Martin, W H; Burk, S H; Kwon, Y; Giragossian, C; Gant, T G // Diabetes;Oct1998, Vol. 47 Issue 10, p1630
The activity of glucose-6-phosphatase (G-6-Pase) in isolated rat microsomes was inhibited by a new selective inhibitor of the multi-subunit G-6-Pase system, 1-[2-(4-chloro-phenyl)-cyclopropylmethoxy]-3,4-dihydroxy-5-(3-imid azo[4,5-b]pyridin-1-yl-3-phenyl-acryloyloxy)-cyclohexanecarboxylic acid...
- Glucose-6-phosphate dehydrogenase deficiency: a preventable cause of mental retardation. Singh, Harcharan // British Medical Journal (Clinical Research Edition);2/8/1986, Vol. 292 Issue 6517, p397
Discusses the role of glucose-6-phosphate in preventing mental retardation. Knowledge of parents and health procedures of the triggering mechanism; Prevention of brain damage by early detection and proper management; Susceptibility of children exposed to acute hemolysis and kernicterus.
- Molecular characterization of glucose-6- phosphate dehydrogenase deficient variants in Baghdad city - Iraq. // BMC Blood Disorders;2012, Vol. 12 Issue 1, p4
The article discusses a study which examined molecular characterization of glucose-6- phosphate dehydrogenase deficient variants in Baghdad, Iraq. The study recruited 1810 apparently healthy adult male blood donors from the national blood transfusion center in Baghdad and classified them into...
- Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence. Ayala, Julio E.; Streeper, Ryan S.; Desgrosellier, Jay S.; Durham, Susan K.; Suwanichkul, Adisak; Svitek, Christina A.; Goldman, Joshua K.; Barr, Frederic G.; Powell, David R.; O'Brien, Richard M.; Ayala, J E; Streeper, R S; Desgrosellier, J S; Durham, S K; Suwanichkul, A; Svitek, C A; Goldman, J K; Barr, F G; Powell, D R; O'Brien, R M // Diabetes;Sep99, Vol. 48 Issue 9, p1885
Because overexpression of the glucose-6-phosphatase catalytic subunit (G-6-Pase) in both type 1 and type 2 diabetes may contribute to the characteristic increased rate of hepatic glucose production, we have investigated whether the insulin response unit (IRU) identified in the mouse G-6-Pase...
- Long-term leptin treatment of ob/ob mice improves glucose-induced insulin secretion. Khan, A; Narangoda, S; Ahren, B; Holm, C; Sundler, F; Efendic, S // International Journal of Obesity & Related Metabolic Disorders;Jun2001, Vol. 25 Issue 6, p816
OBJECTIVE: Previous studies have demonstrated that leptin inhibits glucose-stimulated insulin secretion from isolated islets, although a lack of leptin effect on insulin secretion has also been reported. The effect of long term in vivo leptin treatment of insulin secretion has, however, not been...
- Direct Pathway Metabolism of [U-d7]Glucose in Healthy Humans Reveals Both G6P-Isomerase and Transaldolase Exchanges. Silva, Claudia; Fagulha, Ana; Barros, Luisa; Baptista, Carla; Bastos, Margarida; Carvalheiro, Manuela; Caldeira, Madalena; Barosa, Cristina; Jones, John // Diabetes;Jun2007 Supplement 1, Vol. 56, pA41
Introduction: Hepatic glycogen is synthesized from dietary glucose by direct and indirect pathways. We developed a simple method for quantifying direct and indirect pathway contributions to glycogen synthesis based on the enrichment of positions 5 and 2 of glucuronide from deuterated water. The...
- Is glycogen storage disease 1a associated with atherosclerosis? Ubels, Froukje L.; Rake, Peter; Slaets, Joris J.; Smit, Peter A.; Smit, Andries J. // European Journal of Pediatrics. Supplement;2002, Vol. 161, pS62
Deficiency of microsomal glucose-6-phosphatase in liver and kidney leads to glycogen storage disease type 1a (GSD 1a). Notwithstanding intensive dietary therapy, moderate to severe dyslipidaemia and microalbuminuria, both known atherosclerotic risk factors, remain present. Although more patients...
