Airway inflammation in asthma: basic and clinical science

December 2005
Thorax;Dec2005 Supplement 2, Vol. 60, pii4
Academic Journal
The article presents abstracts related to airway inflammation in asthma. They include "Increased Tachykinin Levels in the Airways of Asthmatic Patients and Chronic Cough Patients With Coexistent Gastro-Oesophageal Reflux Disease," by R.N. Patterson, B.T. Johnston, L.G. Heaney and L.P.A. McGravey, "Clinical and Pathological Features of Non-Eosinophilic Asthma: A Distinct Asthma Phenotype Associated With Inhaled Corticosteroid Resistance," by M.A. Berry, A. Morgan, R.H. Green, C.E. Brightling, A.J. Wardlaw and I.D. Pavord and "Mast Cell Migration to TH2 Stimulated Airway Smooth Muscle From Asthmatics," by A. Sutcliffe, D. Kaur, A.J. Ammit, L. Woodman, J.L. Block, A.J. Wardlaw, P. Bradding, J.M. Hughes and C.E. Brightling.


Related Articles

  • Cyclin D1 in ASM Cells from Asthmatics Is Insensitive to Corticosteroid Inhibition. Allen, Jodi C.; Seidel, Petra; Schlosser, Tobias; Ramsay, Emma E.; Ge, Qi; Ammit, Alaina J. // Journal of Allergy;2012, p1 

    Hyperplasia of airway smooth muscle (ASM) is a feature of the remodelled airway in asthmatics. We examined the antiproliferative effectiveness of the corticosteroid dexamethasone on expression of the key regulator of G1 cell cycle progression-cyclin D1-in ASM cells from nonasthmatics and...

  • The Oxidant-Antioxidant Balance in Mild Asthmatic Patients. Hanta, I.; Kuleci, S.; Canacankatan, N.; Kocabas, A. // Lung;2003, Vol. 181 Issue 6, p347 

    We investigated the oxidant-antioxidant balance and the effect of inhaled corticosteroids on this balance in mild stable asthmatics. Included in the study were 30 mild asthmatic patients (11 male, 19 female, mean age (year) � SD: 35.1 � 9.7) and 26 healthy adults (7 male, 19 female,...

  • Biopharmaceutical Therapeutics for Asthma Remodeling. Das, A. M.; Griswold, D. E.; Torphy, T. J.; Li, L. // Current Pharmaceutical Design;Sep2006, Vol. 12 Issue 25, p3233 

    Current asthma therapy is aimed at controlling disease symptoms. A subset of asthma patients remains symptomatic despite optimal therapy indicating that an unmet medical need exists for these patients. Innovative therapeutics are needed to treat the unmet need in asthma and biopharmaceutical...

  • The Role of Mast Cells in the Structural Alterations of the Airways as a Potential Mechanism in the Pathogenesis of Severe Asthma. Carter, R. J. F.; Bradding, P. // Current Pharmaceutical Design;3/1/2011, Vol. 17 Issue 7, p685 

    No abstract available.

  • Inflammation of bronchial smooth muscle in allergic asthma. Begueret, H.; Berger, P.; Vernejoux, J.-M.; Dubuisson, I.; Marthan, R.; Tunon-de-Lara, J. M. // Thorax;Jan2007, Vol. 62 Issue 1, p8 

    Background: Recent observations in asthma suggest that bronchial smooth muscle is infiltrated by inflammatory cells including mast cells. Such an infiltration may contribute to airway remodelling that is partly due to an increase in smooth muscle mass. Whether muscle increase is the result of...

  • BAZELE PATOGENICE ALE TRATAMENTULUI MEDICAMENTOS ÃŽN ASTMUL BRONÅŸIC LA COPIL. Florea, Maria Magdalena; Goţia, Stela // Romanian Journal of Pediatrics;2011, Vol. 60 Issue 2, p144 

    No abstract available.

  • Pathogenic pathways of drug therapy in child's asthma. Florea, Maria Magdalena; Gotia, Stela // Romanian Journal of Pediatrics;2011, Vol. 60 Issue 2, p150 

    Asthmatic airways inflammation with still unknown various pathways involves multiple components and is orchestrated by numerous cell types, particularly mast cell, eosinophils, and CD4+ lymphocytes, but also airway structural cells. By there activation release over 100 pro-inflammatory mediators...

  • What best prevents exercise-induced bronchoconstriction for a child with asthma? Preston, Jeffrey; Cucuzzella, Mark; Jamieson, Barbara // Journal of Family Practice;Jul2006, Vol. 55 Issue 7, p631 

    The article provides information regarding the effective ways in preventing exercise-induced bronchoconstriction for a child with asthma. Inhaled short-acting beta-agonists are considered to be the most effective way in preventing exercise-induced bronchoconstriction, followed by inhaled mast...

  • Breath Formate Is a Marker of Airway S-Nitrosothiol Depletion in Severe Asthma. Greenwald, Roby; Fitzpatrick, Anne M.; Gaston, Benjamin; Marozkina, Nadzeya V.; Erzurum, Serpil; Teague, W. Gerald // PLoS ONE;2010, Vol. 5 Issue 7, p1 

    Background: Children with severe asthma have poor symptom control and elevated markers of airway oxidative and nitrosative stress. Paradoxically, they have decreased airway levels of S-nitrosothiols (SNOs), a class of endogenous airway smooth muscle relaxants. This deficiency results from...


Read the Article


Sign out of this library

Other Topics