TITLE

Asthma: mechanisms of disease

PUB. DATE
December 2004
SOURCE
Thorax;Dec2004 Supplement, Vol. 59, p89
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
The article presents some papers related to mechanisms of asthma. Mast cells infiltrate the airway smooth muscle (ASM) of patients with asthma but not those with eosinophilic bronchitis, which is likely to be a key factor in the development of asthma. It is hypothesized that human lung mast cells (HLMC) and ASM co-localize through a specific cell-cell adhesion mechanism, which is predicted to enhance the functional interaction between these two cell types. It is therefore investigated the adhesion of HLMC and the HLMC-1 human mast cell line to primary cultures of ASM. HLMC and ASM were isolated from lung resection specimens.
ACCESSION #
17564538

 

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