Asthma: mechanisms of disease

December 2004
Thorax;Dec2004 Supplement, Vol. 59, p89
Academic Journal
The article presents some papers related to mechanisms of asthma. Mast cells infiltrate the airway smooth muscle (ASM) of patients with asthma but not those with eosinophilic bronchitis, which is likely to be a key factor in the development of asthma. It is hypothesized that human lung mast cells (HLMC) and ASM co-localize through a specific cell-cell adhesion mechanism, which is predicted to enhance the functional interaction between these two cell types. It is therefore investigated the adhesion of HLMC and the HLMC-1 human mast cell line to primary cultures of ASM. HLMC and ASM were isolated from lung resection specimens.


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