Genetic susceptibility to lung disease
Related Articles
- Associations of IL6 polymorphisms with lung function decline and COPD. He, J.-Q.; Foreman, M. G.; Shumansky, K.; Zhang, X.; Akhabir, L.; Sin, D. D.; Man, S. F. P.; DeMeo, D. L.; Litonjua, A. A.; Silverman, E. K.; Connett, J. E.; Anthonisen, N. R.; Wise, R. A.; Paré, P. D.; Sandford, A. J. // Thorax;Aug2009, Vol. 64 Issue 8, p14
Background: Interleukin-6 (IL6) is a pleiotropic pro-inflammatory and immunomodulatory cytokine which probably plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). There is a functional single nucleotide polymorphism (SNP), -174G/C, in the promoter region...
- Association between IL-6 −174 G/C, IL-6 −634 G/C, and IFN-γ +874 A/T polymorphisms and susceptibility to recurrent pregnancy loss: a meta-analysis. Lee, Young; Choi, Sung; Ji, Jong // Journal of Assisted Reproduction & Genetics;Sep2015, Vol. 32 Issue 9, p1421
Objective: The aim of this study was to determine whether interleukin-6 ( IL-6) −174 G/C, IL-6 −634 G/C, and interferon-γ ( IFN-γ) +874 A/T polymorphisms are associated with susceptibility to recurrent pregnancy loss (RPL). Methods: We conducted a literature search using PubMed...
- Less Frequent and Less Severe Flu-Like Syndrome in Interferon Beta-1a Treated Multiple Sclerosis Patients with at Least One Allele Bearing the G>C Polymorphism at Position -174 of the IL-6 Promoter Gene. Bertoli, Diego; Serana, Federico; Sottini, Alessandra; Cordioli, Cinzia; Maimone, Davide; Amato, Maria Pia; Centonze, Diego; Florio, Ciro; Puma, Elisa; Capra, Ruggero; Imberti, Luisa // PLoS ONE;8/18/2015, Vol. 10 Issue 8, p1
One of the most common adverse event of interferon beta (IFNβ) therapy for multiple sclerosis is flu-like syndrome (FLS), which has been reportedly related to increased levels of cytokines such as interleukin 6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Average cytokine levels can be...
- Allele associations reveal four prominent haplotypes at the human interleukin-6 (IL-6) locus. Jordanides, N; Eskdale, J; Stuart, R; Gallagher, G // Genes & Immunity;Oct2000, Vol. 1 Issue 7, p451
We have examined four polymorphic elements in the human interleukin-6 (IL-6) locus and described their allele distribution in 73 unrelated, healthy individuals from the West-of-Scotland. These comprised three single nucleotide polymorphisms (SNP) in the 5' promoter region of the gene and one...
- Haptoglobin gene polymorphisms and interleukin-6 and -8 levels in patients with sickle cell anemia. Pierrot-Gallo, Bruna Spinella; Vicari, Perla; Satiko Matsuda, Sandra; Ademola Adegoke, Samuel; Mecabo, Grazielle; Figueiredo, Maria Stella // Revista Brasileira de Hematologia e Hemoterapia;Sep/Oct2015, Vol. 37 Issue 5, p329
Background: Haptoglobin genotypes, and interleukin-6 and -8 participate in the pathophysi-ology of sickle cell anemia. The expression of cytokines is regulated by genetic mechanisms however the effect of haptoglobin polymorphisms on these cytokines is not fully understood. This study aimed to...
- A novel single nucleotide polymorphism and five probable haplotypes in the 5′ flanking region of the IL-6 gene in African-Americans. Osiri, M; McNicholl, J; Moreland, L W; Bridges, S Louis // Genes & Immunity;Nov99, Vol. 1 Issue 2, p166
In order to identify novel single nucleotide polymorphisms (SNPs), we sequenced a 940 bp region of the 5' flanking region of the IL-6 gene in 63 normal African-Americans. We identified a biallelic (G/C) SNP at position -573 relative to the transcription start site (-573C allele frequency 0.095)....
- Genetic polymorphisms associated with increased risk for upper respiratory tract infections, acute otitis media. // Infectious Diseases in Children;Aug2009, Vol. 22 Issue 8, p47
The article discusses research which revealed that children with interleukin -6 and tumor necrosis factor-α polymorphisms experienced more frequent and complicated upper respiratory tract infections compared with children without the genetic characteristics, referencing a study by K. Reval...
- Association between interleukin-6 receptor gene variations and atherosclerotic lipid profiles among young adolescents in Taiwan. // Lipids in Health & Disease;2011, Vol. 10 Issue 1, p136
The article cites a research study that analyzes the potential genetic associations between four polymorphisms of interleukin-6 receptor (IL-6R) gene and atherosclerotic lipid profiles. The study included 418 boys and 441 girls with an average age of 13.1 years in Taiwan. It used data from the...
- Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease: Results of a pilot study. Bagli, Metin; Papassotiropoulos, Andreas; Hampel, Harald; Becker, Karin; Jessen, Frank; Bürger, Katharina; Ptok, U.; Rao, Marie Luise; Möller, Hans-Jürgen; Maier, Wolfgang; Heun, Reinhard // European Archives of Psychiatry & Clinical Neuroscience;2003, Vol. 253 Issue 1, p44
Interleukin-6 (IL-6) is a multifunctional cytokine involved in the pathogenesis of Alzheimer's disease (AD). The effects of IL-6 are mediated through a specific receptor complex made up of a ligand binding glycoprotein (gp80 or IL-6R) and a signal transducing glycoprotein (gp130). Conflicting...
