Pulmonary fibrosis: molecular mechanisms

December 2004
Thorax;Dec2004 Supplement, Vol. 59, p41
Academic Journal
The article presents abstracts of papers on the molecular mechanism of pulmonary fibrosis. One of the studies report on idiopathic pulmonary fibrosis, which is a progressive fibrotic lung disease that poses a therapeutic challenge because no treatment has a consistent impact on disease progression. Another study reports that simvastatin inhibits growth factor expression and modulates profibrotic markers in human lung fibroblasts. A separate study informs that a novel transforming growth factor beta transcriptional targets in adult lung fibroblasts has been identified by microarray analysis.


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