Cytokines and chemokines in lung disease

December 2004
Thorax;Dec2004 Supplement, Vol. 59, p4
Academic Journal
This article presents abstracts of several medical studies conducted to test the role of cytokines and chemokines in lung disease. EBI3-p35 is a heterodimeric cytokine consisting of EBI3 and the p35 chain of IL-12. It has a potent anti-inflammatory effect both in vitro and in vivo. It was hypothesised therefore that EBI3-p35 may have a therapeutic function in allergic disease and this was tested in a standard murine model of ovalbumin induced airway sensitisation. Refractory asthma occurs in about 5% of patients with asthma. It causes considerable morbidity and mortality and accounts for a disproportionately large amount of the health resource burden attributed to asthma.


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