TITLE

Cytokines and chemokines in lung disease

PUB. DATE
December 2004
SOURCE
Thorax;Dec2004 Supplement, Vol. 59, p4
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
This article presents abstracts of several medical studies conducted to test the role of cytokines and chemokines in lung disease. EBI3-p35 is a heterodimeric cytokine consisting of EBI3 and the p35 chain of IL-12. It has a potent anti-inflammatory effect both in vitro and in vivo. It was hypothesised therefore that EBI3-p35 may have a therapeutic function in allergic disease and this was tested in a standard murine model of ovalbumin induced airway sensitisation. Refractory asthma occurs in about 5% of patients with asthma. It causes considerable morbidity and mortality and accounts for a disproportionately large amount of the health resource burden attributed to asthma.
ACCESSION #
17564499

 

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