Cell/molecular biology posters

April 2005
Gut;Apr2005 Supplement 2, Vol. 54, pA86
Academic Journal
The article presents information on abstracts related to cell and molecular biology. An abstract presents information on the detection and characterization of tp53 mutations in tumours of the oesophagus and cardia from an area of high incidence. The p53 protein is a transcription factor involved in key processes such as cell cycle control, apoptosis, and DNA repair. Alterations to the TP53 gene are considered one of the most common genetic alterations in cancers. Screening for and identifying TP53 mutations in tumours could be of use clinically to improve prognosis and therapy for digestive cancers. The aim was to compare the sensitivity and specificity of denaturing high performance liquid chromatography with conventional TP53 mutation detection by denaturing gradient gel electrophoresis. The former technique has advantages of minimal sample handling and a throughput suitable for clinical applications.


Related Articles

  • Research highlights.  // Nature Structural & Molecular Biology;Feb2007, Vol. 14 Issue 2, p102 

    The article highlights studies on molecular biology. The interaction of the RTK/Ras pathway to TGF-Î’ pathway stimulation is integrated as the p53 tumor suppressor. It was found that the HIV behaves like a pinball machine when it encodes a Tat small protein that activates viral gene...

  • Research highlights.  // Nature;6/14/2007, Vol. 447 Issue 7146, p756 

    The article reports on development related to research. Researchers from the University of Bonn showed that inhibiting cannabinoid receptors either genetically or chemically enhances skin hypersensitivity to allergens in mice. Meanwhile, researchers at the University of Texas analyzed 133...

  • Down regulation of PSA by C/EBPα is associated with loss of AR expression and inhibition of PSA promoter activity in the LNCaP cell Line. Yin, Hong; Radomska, Hanna S; Tenen, Daniel G; Glass, Jonathan // BMC Cancer;2006, Vol. 6, p158 

    Background: C/EBPa is a transcription factor essential for terminal differentiation of several cell types. It has not known if C/EBPα protein is expressed and functions in the prostate gland. Methods: The presence of C/EBPα in normal and cancerous prostate epithelium was examined by...

  • Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study. Burwinkel, Barbara; Shanmugam, Kalai S.; Hemminki, Kari; Meindl, Alfons; Schmutzler, Rita K.; Sutter, Christian; Wappenschmidt, Barbara; Kiechle, Marion; Bartram, Claus R.; Frank, Bernd // BMC Cancer;2006, Vol. 6, p268 

    Background: The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/β-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect...

  • Transcription profiles of non-immortalized breast cancer cell lines. Fernandez-Cobo, Mariana; Holland, James F; Pogo, Beatriz GT // BMC Cancer;2006, Vol. 6, p99 

    Background: Searches for differentially expressed genes in tumours have made extensive use of array technology. Most samples have been obtained from tumour biopsies or from established tumour-derived cell lines. Here we compare cultures of non-immortalized breast cancer cells, normal...

  • Down-regulation of transcription elogation factor A (SII) like 4 (TCEAL4) in anaplastic thyroid cancer. Akaishi, Junko; Onda, Masamitsu; Okamoto, Junichi; Miyamoto, Shizuyo; Nagahama, Mitsuji; Ito, Kouichi; Yoshida, Akira; Shimizu, Kazuo // BMC Cancer;2006, Vol. 6, p1 

    Background: Anaplastic thyroid cancer (ATC) is one of the most aggressive human malignancies and appears to arise mainly from transformation of pre-existing differentiated thyroid cancer (DTC). However, the carcinogenic mechanism of anaplastic transformation remains unclear. Previously, we...

  • Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours. Jacques, C.; Fontaine, J-F.; Franc, B.; Mirebeau-Prunier, D.; Triau, S.; Savagner, F.; Malthiery, Y. // British Journal of Cancer;7/7/2009, Vol. 101 Issue 1, p132 

    Background:The human death-associated protein 3 (hDAP3) is a GTP-binding constituent of the small subunit of the mitochondrial ribosome with a pro-apoptotic function.Methods:A search through publicly available microarray data sets showed 337 genes potentially coregulated with the DAP3 gene. The...

  • Microphthalmia transcription factor and NKI/C3 expression in cellular neurothekeoma. Page, Robert N.; King, Roy; Martin Jr., Martin C.; Googe, Paul B. // Modern Pathology;Feb2004, Vol. 17 Issue 2, p230 

    While the usual or myxoid-type neurothekeoma has been reasonably well established as being a tumor of neural origin, the cellular neurothekeoma remains in disputed histogenesis. We studied a series of ii cellular neurothekeomas using paraffin immunoperoxidase staining with microphthalmia...

  • Molecular Mechanisms of Barrett's Esophagus. Chen, Hao; Fang, Yu; Tevebaugh, Whitney; Orlando, Roy; Shaheen, Nicholas; Chen, Xiaoxin // Digestive Diseases & Sciences;Dec2011, Vol. 56 Issue 12, p3405 

    Barrett's esophagus (BE) is defined as the metaplastic conversion of esophageal squamous epithelium to intestinalized columnar epithelium. As a premalignant lesion of esophageal adenocarcinoma (EAC), BE develops as a result of chronic gastroesophageal reflux disease (GERD). Many studies have...


Read the Article


Sign out of this library

Other Topics