Cell/molecular biology posters

April 2005
Gut;Apr2005 Supplement 2, Vol. 54, pA86
Academic Journal
The article presents information on abstracts related to cell and molecular biology. An abstract presents information on the detection and characterization of tp53 mutations in tumours of the oesophagus and cardia from an area of high incidence. The p53 protein is a transcription factor involved in key processes such as cell cycle control, apoptosis, and DNA repair. Alterations to the TP53 gene are considered one of the most common genetic alterations in cancers. Screening for and identifying TP53 mutations in tumours could be of use clinically to improve prognosis and therapy for digestive cancers. The aim was to compare the sensitivity and specificity of denaturing high performance liquid chromatography with conventional TP53 mutation detection by denaturing gradient gel electrophoresis. The former technique has advantages of minimal sample handling and a throughput suitable for clinical applications.


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