Neoplasia posters

April 2005
Gut;Apr2005 Supplement 2, Vol. 54, pA56
Academic Journal
The article presents information on abstracts related to neoplasia. An abstract informs that helicobacter pylori stimulated epithelial ERK phosphorylation is reduced by the specific EGFR inhibitor EKB-569. H. pylori activates multiple signaling pathways in gastric epithelial cells, including transactivation of the EGF receptor (EGFR) and activation of MAP kinases, extracellular signal related kinases 1 and ERK2. H pylori activation of the EGFR signalling pathway may be relevant to the epithelial hyperproliferation and increased risk of gastric carcinogenesis associated with infection. The aims of this study were to evaluate whether H pylon induced phosphorylation of ERK is via the EGF receptor.


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